公开(公告)号：US10793542B2

公开(公告)日：2020-10-06

申请号：US16462589

申请日：2017-11-22

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Mann-Yan Kuo ,  Ying-Shuan Lee ,  Yann-Yu Lu ,  Chia-Wei Liu ,  Seline Hsieh ,  Ju-Ying Yang

IPC: C07D213/74 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  A61P35/00 ,  C07D239/38 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  A61K45/06

Abstract: The present invention provides a compound of formula (1): wherein X, Y, Z1, Z2, R1, R2, A, B, p and q are as disclosed in the specification. A pharmaceutical composition and a method for modulating the Hedgehog pathway are also provided. The present invention rurthe r provides a process for preparing the compound.