公开(公告)号：US09801888B2

公开(公告)日：2017-10-31

申请号：US15002806

申请日：2016-01-21

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY ,  DCB-USA LLC

Inventor： Mann-Yan Kuo ,  Ying-Shuan Lee ,  Paonien Chen ,  Li Jung Chen ,  Yann Yu Lu ,  Yi-Ting Huang ,  Hung-Yi Hsu ,  Ping-Kuei Tsai

IPC: A61K31/5377 ,  A61K31/541 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D403/12 ,  C07D401/14 ,  C07D239/47 ,  C07D409/12 ,  C07D413/12 ,  A61K45/06 ,  C07D401/04

CPC classification number: A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D239/47 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

Abstract: The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

公开(公告)号：US10793542B2

公开(公告)日：2020-10-06

申请号：US16462589

申请日：2017-11-22

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Mann-Yan Kuo ,  Ying-Shuan Lee ,  Yann-Yu Lu ,  Chia-Wei Liu ,  Seline Hsieh ,  Ju-Ying Yang

IPC: C07D213/74 ,  C07D239/47 ,  C07D239/48 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  A61P35/00 ,  C07D239/38 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  A61K45/06

Abstract: The present invention provides a compound of formula (1): wherein X, Y, Z1, Z2, R1, R2, A, B, p and q are as disclosed in the specification. A pharmaceutical composition and a method for modulating the Hedgehog pathway are also provided. The present invention rurthe r provides a process for preparing the compound.

公开(公告)号：US09315491B2

公开(公告)日：2016-04-19

申请号：US14192301

申请日：2014-02-27

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY ,  DCB-USA LLC

Inventor： Mann-Yan Kuo ,  Ying-Shuan Lee ,  Paonien Chen ,  Li Jung Chen ,  Yann Yu Lu ,  Yi-Ting Huang ,  Hung-Yi Hsu ,  Ping-Kuei Tsai

IPC: A61K31/5377 ,  C07D239/47 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14 ,  C07D413/04 ,  A61K31/541 ,  A61K45/06 ,  C07D413/14 ,  C07D417/14 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

CPC classification number: A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D239/47 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

Abstract: The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

Abstract translation: 本发明涉及式（I）的嘧啶化合物：其可用于治疗mTOR激酶或PI3K激酶相关疾病。

公开(公告)号：US20140178360A1

公开(公告)日：2014-06-26

申请号：US14192301

申请日：2014-02-27

Applicant: DCB-USA LLC ,  DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Mann-Yan KUO ,  Ying-Shuan Lee ,  Paonien Chen ,  Li Jung Chen ,  Yann Yu Lu ,  Yi-Ting Huang ,  Hung-Yi Hsu ,  Ping-Kuei Tsai

IPC: C07D413/04 ,  A61K31/541 ,  A61K45/06 ,  A61K31/5377 ,  C07D413/14 ,  C07D417/14

CPC classification number: A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D239/47 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61K2300/00

Abstract: The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

Abstract translation: 本发明涉及式（I）的嘧啶化合物：其可用于治疗mTOR激酶或PI3K激酶相关疾病。