公开(公告)号：US20240222103A1

公开(公告)日：2024-07-04

申请号：US18569773

申请日：2022-06-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Takashi BABA ,  Keqin CHEN

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/08 ,  H01J49/36

CPC classification number: H01J49/0054 ,  H01J49/022 ,  H01J49/08 ,  H01J49/36

Abstract: In one aspect, an electron capture dissociation (ECD) device for use in a mass spectrometer is disclosed, which is configured to trap precursor ions and cause the trapped precursor ions (or a portion thereof) to exit the ion trap, via radial excitation thereof by a resonant AC voltage, such that the released precursor ions can enter an ion-electron interaction region in which at least a portion of the precursor ions undergo fragmentation via interaction with an electron beam. The fragment ions are trapped and prevented from undergoing multiple dissociations. Once the fragmentation of the precursor ions is completed and/or after a predefined period, the fragment ions are released from the ECD to be received by downstream components of the mass spectrometer in which the ECD device is incorporated.