公开(公告)号：US3847986A

公开(公告)日：1974-11-12

申请号：US40147573

申请日：1973-09-27

Applicant: DOW CHEMICAL CO

Inventor： BOCKSTAHLER E

IPC: C07C259/14 ,  C07C123/00

CPC classification number: C07C259/14

Abstract: 1. A SUBSTITUTED PHENYLTHIO AMIDINE COMPOUND OF THE FORMULA:

R-(1,4-PHENYLENE)-S-CH2-C(-NH)=N-OH

WHEREIN R REPRESENTS HALO OR A SALT THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID.

公开(公告)号：US3775478A

公开(公告)日：1973-11-27

申请号：US3775478D

申请日：1972-05-30

Applicant: DOW CHEMICAL CO

Inventor： BOCKSTAHLER E

IPC: C07C259/14 ,  C07C123/00

CPC classification number: C07C259/14

Abstract: SUBSTITUTED PHENYLTHIOAMIDE COMPOUNDS SUCH AS 2-(4CHLOROPHENYLTHIO)ACETAMIDINE; 2-(4 - RHLOROPHENYLTHIO)ACETAMIDOXIME; AND THEIR PHARAMACEUTICALLY-ACCEPTABLE SALTS ARE PREPARED BY THE REACTION OF A SUBSTITUTED PHENYLTHIOACETONITRILE WITH HYDROXYLAMINE HYDROCHLORIDE OR WITH METHANOL FOLLOWED BY AMMONIUM CHLORIDE. THE COMPOUNDS HAVE ANTIMICROBIAL ACTIVITY AND ALSO INHIBIT ADPINDUCED AGGREGATION OF BLOOD PLATELETS.