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公开(公告)号：US20060020008A1
公开(公告)日：2006-01-26
申请号：US11154989
申请日：2005-06-15
申请人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David Morgans , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Christopher Brook
发明人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David Morgans , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Christopher Brook
IPC分类号： A61K31/4178 , C07D405/02
CPC分类号： C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US20080004308A1
公开(公告)日：2008-01-03
申请号：US11835434
申请日：2007-08-08
申请人： Dashyant Dhanak , Kenneth Newlander
发明人： Dashyant Dhanak , Kenneth Newlander
IPC分类号： A61K31/4745 , A61P35/00 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译： 本发明涉及由式（I）表示的化合物及其药学上可接受的盐。 本发明的化合物抑制Aurora激酶，使其特别适用于治疗许多疾病，包括实体瘤癌症和血液癌症。
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公开(公告)号：US20070149561A1
公开(公告)日：2007-06-28
申请号：US11612531
申请日：2006-12-19
申请人： Dashyant DHANAK , Kenneth Newlander
发明人： Dashyant DHANAK , Kenneth Newlander
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译： 本发明涉及由式（I）表示的化合物及其药学上可接受的盐。 本发明的化合物抑制Aurora激酶，使其特别适用于治疗许多疾病，包括实体瘤癌症和血液癌症。
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公开(公告)号：US20080081808A1
公开(公告)日：2008-04-03
申请号：US11855183
申请日：2007-09-14
申请人： Martha Sarpong , Nicholas Adams , Jeffrey Axten , Amita Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Newlander , Cynthia Parrish , Jerry Adams , Domingos Silva , Jun Tang
发明人： Martha Sarpong , Nicholas Adams , Jeffrey Axten , Amita Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Newlander , Cynthia Parrish , Jerry Adams , Domingos Silva , Jun Tang
IPC分类号： A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/54 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
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公开(公告)号：US20070135432A1
公开(公告)日：2007-06-14
申请号：US11600683
申请日：2006-11-15
申请人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
发明人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
IPC分类号： C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/513
CPC分类号： C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译： 公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：US20060052360A1
公开(公告)日：2006-03-09
申请号：US10538228
申请日：2003-12-12
申请人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
发明人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
IPC分类号： A61K31/554 , A61K31/55 , A61K31/553 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US20070254870A1
公开(公告)日：2007-11-01
申请号：US11788784
申请日：2007-04-19
申请人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
发明人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
IPC分类号： A61K31/551 , C07D243/00 , C12N9/99
CPC分类号： C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US20070219192A1
公开(公告)日：2007-09-20
申请号：US11592737
申请日：2006-11-02
IPC分类号： A61K31/5383 , A61K31/426 , A61K31/4745 , A61K31/4172 , A61K31/4184
CPC分类号： C07D233/61 , A61K31/4172 , A61K31/4184 , A61K31/426 , A61K31/4745 , A61K31/5383 , C07C217/70 , C07C235/34 , C07C237/22 , C07C275/24 , C07C307/06 , C07D233/14 , C07D233/64
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
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公开(公告)号：US08637509B2
公开(公告)日：2014-01-28
申请号：US13696601
申请日：2011-05-05
申请人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis LaFrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号： A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号： C07D471/04 , C07D519/00
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译： 本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。
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公开(公告)号：US20130059849A1
公开(公告)日：2013-03-07
申请号：US13696601
申请日：2011-05-05
申请人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
发明人： Joelle Lorraine Burgess , Neil Johnson , Steven D. Knight , Louis Lafrance , William H. Miller , Kenneth Newlander , Stuart Romeril , Meagan B. Rouse , Xinrong Tian , Sharad Kumar Verma , Dominic Suarez
IPC分类号： A61K31/444 , A61P35/00 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/513 , C07D471/04 , A61K31/4545
CPC分类号： C07D471/04 , C07D519/00
摘要： Herein are disclosed azaindazoles of formula (I) where the various groups are defined herein, and which are useful for treating cancer.
摘要翻译： 本文公开了式（I）的氮杂吲唑，其中各种基团在本文中定义，并且其可用于治疗癌症。
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