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公开(公告)号：US11987560B2
公开(公告)日：2024-05-21
申请号：US17356389
申请日：2021-06-23
发明人： Young K. Chen , Toufike Kanouni , Stephen W. Kaldor , Jeffrey Alan Stafford , James Marvin Veal
IPC分类号： C07D239/47 , A61K31/4545 , A61K31/513 , A61K31/5377 , A61K31/551 , C07B59/00 , C07D239/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/10
CPC分类号： C07D239/47 , A61K31/4545 , A61K31/513 , A61K31/5377 , A61K31/551 , C07B59/002 , C07D239/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/10 , C07B2200/05
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US11851449B2
公开(公告)日：2023-12-26
申请号：US17316185
申请日：2021-05-10
发明人： Satoshi Yamamoto , Junya Shirai , Mitsunori Kono , Yoshihide Tomata , Ayumu Sato , Atsuko Ochida , Yoshiyuki Fukase , Shoji Fukumoto , Tsuneo Oda , Hidekazu Tokuhara , Naoki Ishii , Yusuke Sasaki
IPC分类号： C07F7/08 , C07D205/04 , C07D207/12 , C07K5/065 , C07D239/36 , C07D213/64 , C07D309/06 , C07D333/38 , C07F7/10 , C07D403/06 , C07D271/10 , C07C237/22 , C07D295/14 , C07D207/26 , C07D413/12 , C07F7/30 , C07D233/72 , C07D309/08 , C07D231/56 , C07D261/08 , C07D209/18 , C07D405/12 , C07D261/12 , C07D239/54 , C07D211/62 , C07D237/14 , C07D231/12 , C07D487/04 , A61P43/00 , A61P29/00 , A61P25/00 , A61P19/02 , A61P17/06 , A61P1/04 , C07K5/087
CPC分类号： C07F7/0812 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P43/00 , C07C237/22 , C07D205/04 , C07D207/12 , C07D207/26 , C07D209/18 , C07D211/62 , C07D213/64 , C07D231/12 , C07D231/56 , C07D233/72 , C07D237/14 , C07D239/36 , C07D239/54 , C07D261/08 , C07D261/12 , C07D271/10 , C07D295/14 , C07D309/06 , C07D309/08 , C07D333/38 , C07D403/06 , C07D405/12 , C07D413/12 , C07D487/04 , C07F7/081 , C07F7/10 , C07F7/30 , C07K5/06078 , C07K5/0812
摘要： The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.
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公开(公告)号：US20180208552A1
公开(公告)日：2018-07-26
申请号：US15576345
申请日：2016-05-26
发明人： Hiroyasu TAKAHASHI , Hiroyuki WATANABE , Kiyoshi FUJII , Mitsuhito SHIBASAKI , Mikako KAWASHIMA , Megumi KAMIYA , Kohei OHATA
IPC分类号： C07C275/30 , C07C275/42 , C07C275/50 , C07D231/12 , C07D285/08 , C07D285/135 , C07D271/113 , C07D271/07 , C07D239/36 , A61P29/00 , A61P35/00 , A61P31/18
CPC分类号： C07C275/30 , A61P29/00 , A61P31/18 , A61P35/00 , C07B2200/07 , C07C275/42 , C07C275/50 , C07C311/51 , C07C317/32 , C07C317/40 , C07C2601/02 , C07D213/61 , C07D231/12 , C07D239/36 , C07D249/04 , C07D249/08 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/32 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D273/04 , C07D277/28 , C07D285/08 , C07D285/12 , C07D285/135 , C07D307/79 , C07D311/58 , C07D333/16 , C07D333/28 , C07D413/04 , C07D413/12 , C07D417/12
摘要： The present invention provides a urea compound or a pharmacologically acceptable salt thereof that has a formyl peptide receptor like 1 (hereinafter may be abbreviated as FPRL1) agonist effect, a pharmaceutical composition containing the urea compound or the pharmacologically acceptable salt thereof, and a pharmaceutical use thereof. It has been found that a urea derivative represented by the general formula (I) below or a pharmacologically acceptable salt thereof has a superior FPRL1 agonist effect. Compound (I) or a pharmacologically acceptable salt thereof is highly useful for treatment, prevention, or suppression of inflammatory diseases, chronic airway diseases, cancers, septicemia, allergic symptoms, HIV retrovirus infection, circulatory disorders, neuroinflammation, nervous disorders, pains, prion diseases, amyloidosis, immune disorders and the like.
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公开(公告)号：US09815796B2
公开(公告)日：2017-11-14
申请号：US15107233
申请日：2014-12-17
发明人： Dong Ming Shen , Melissa Egbertson , Richard Berger , XiaoXia Qian , Yimin Qian , Bart Harper , Meng Yang , Zack Zhiqiang Guo , Vanessa L. Rada , Deping Wang , Timothy A. Cernak , Christopher Sinz , Ming Wang , Jonathan E. Wilson , Shimin Xu
IPC分类号： C07D239/36 , C07D401/12 , C07D401/06 , C07D403/04 , C07D403/14 , C07D487/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D403/12 , C07D403/06
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
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公开(公告)号：US20170320895A1
公开(公告)日：2017-11-09
申请号：US15599769
申请日：2017-05-19
发明人： Roland Gendron , Melissa Fleury , Adam D. Hughes
IPC分类号： C07D498/08 , A61K31/42 , C07D413/12 , C07D413/06 , C07D413/04 , C07D409/06 , C07D405/12 , C07D403/06 , C07D403/04 , C07D401/06 , C07D401/04 , C07D333/70 , C07D333/40 , C07D307/68 , C07D277/56 , C07D277/46 , C07D271/06 , C07D263/56 , C07D263/34 , C07D261/20 , C07D261/18 , C07D261/12 , C07D257/04 , C07D249/18 , C07D249/12 , C07D249/10 , C07D249/08 , C07D249/04 , C07D241/24 , C07D239/36 , C07D239/34 , C07D237/24 , C07D237/04 , C07D233/90 , C07D233/26 , C07D231/14 , C07D213/81 , C07D213/80 , C07D213/79 , C07D207/34 , A61K45/06 , A61K31/5377 , A61K31/422 , C07D471/04 , C07D498/04
CPC分类号： C07D498/08 , A61K31/42 , A61K31/422 , A61K31/5377 , A61K45/06 , C07D207/34 , C07D213/79 , C07D213/80 , C07D213/81 , C07D231/14 , C07D233/26 , C07D233/90 , C07D237/04 , C07D237/24 , C07D239/34 , C07D239/36 , C07D241/24 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D261/20 , C07D263/34 , C07D263/56 , C07D271/06 , C07D277/46 , C07D277/56 , C07D307/68 , C07D333/40 , C07D333/70 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/12 , C07D409/06 , C07D413/04 , C07D413/06 , C07D413/12 , C07D471/04 , C07D498/04
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号：US20170320888A1
公开(公告)日：2017-11-09
申请号：US15445673
申请日：2017-02-28
发明人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Willy Moree , Martin Rowbottom , Warren Wade , Liren Zhao , Richard Lowe , Nicole Smith , Neil Ashweek , Yun-Fei Zhu
IPC分类号： C07D495/04 , C07C233/88 , C07D401/12 , C07D401/04 , C07D239/36 , C07D215/54 , C07D215/14 , C07D213/89 , C07D213/84 , C07D213/81 , C07D213/70 , C07D213/64 , C07D213/61 , C07D213/58 , C07D213/56 , C07C255/57 , C07C235/42 , C07D413/12 , C07D417/12
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
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公开(公告)号：US09802930B1
公开(公告)日：2017-10-31
申请号：US15515868
申请日：2015-09-18
IPC分类号： A61K31/54 , C07D417/14 , C07D239/34 , A01N43/54 , C07D239/36 , C07D401/04 , C07D401/14 , A01N43/653 , A01N43/78 , A01N43/84
CPC分类号： C07D417/14 , A01N43/54 , A01N43/653 , A01N43/78 , A01N43/84 , A61K31/506 , A61K31/513 , C07D239/34 , C07D239/36 , C07D239/40 , C07D401/04 , C07D401/14
摘要： A pyrimidinone compound represented by formula (1): [wherein: A1 represents a nitrogen atom or a CR4; A2 represents a nitrogen atom and A3 represents a CR3b, or A2 represents a CR3a and A3 represents a nitrogen atom; Q represents an oxygen atom or a sulfur atom; G represents a C2-C10 chain hydrocarbon group having one or more halogen atoms, etc.; R1 represents a C1-C6 chain hydrocarbon group optionally having one or more halogen atoms; R2 represents a C1-C6 chain hydrocarbon group optionally having one or more halogen atoms, etc.; R4 represents a hydrogen atom, etc.; R3, R3a, and R3b represent independently of each other a hydrogen atom, etc.; n represents 0, 1, or 2; and p represents 0, 1, 2, or 3] has an excellent efficacy for controlling harmful arthropods.
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公开(公告)号：US09776974B2
公开(公告)日：2017-10-03
申请号：US15401894
申请日：2017-01-09
发明人： Young K. Chen , Toufike Kanouni , Stephen W. Kaldor , Jeffrey Alan Stafford , James Marvin Veal
IPC分类号： C07D239/36 , A61K31/513 , C07D239/47 , C07D401/04 , C07D401/14 , C07D405/14 , C07D403/04 , A61K31/4545 , C07D401/12 , C07D471/10 , C07B59/00 , C07D403/14 , C07D403/12
CPC分类号： C07D239/47 , A61K31/4545 , A61K31/513 , C07B59/002 , C07B2200/05 , C07D239/36 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/10
摘要： The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.
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公开(公告)号：US09725448B2
公开(公告)日：2017-08-08
申请号：US15270187
申请日：2016-09-20
发明人： Melissa Fleury , Roland Gendron , Adam D. Hughes , Cameron Smith
IPC分类号： C07D471/04 , A61K45/06 , A61K31/42 , C07D239/34 , A61K31/505 , C07D231/14 , A61K31/415 , C07D231/20 , C07D249/04 , A61K31/4192 , C07D249/10 , A61K31/4196 , C07D249/18 , A61K31/437 , C07D261/18 , C07D239/36 , C07D257/04 , C07D261/12 , C07D403/04 , C07C271/22 , C07C243/28 , C07D487/04
CPC分类号： C07D471/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/437 , A61K31/505 , A61K45/06 , C07C243/28 , C07C271/22 , C07C2601/02 , C07D231/14 , C07D231/20 , C07D239/34 , C07D239/36 , C07D249/04 , C07D249/10 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D403/04 , C07D487/04
摘要： In one aspect, the invention relates to compounds having the formula: where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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公开(公告)号：US20170217959A1
公开(公告)日：2017-08-03
申请号：US15379188
申请日：2016-12-14
发明人： Cameron Smith , Ryan Hudson , Adam D. Hughes
IPC分类号： C07D471/04 , A61K31/415 , A61K31/4155 , C07D401/06 , A61K31/454 , A61K31/5377 , C07D261/12 , A61K31/42 , C07D249/10 , A61K31/4196 , C07D249/04 , A61K31/4192 , A61K31/437 , C07D249/18 , C07D257/04 , A61K31/41 , C07D401/04 , A61K31/4439 , C07D403/04 , A61K31/497 , C07D263/32 , A61K31/421 , C07D239/34 , A61K31/505 , C07D277/34 , A61K31/426 , C07D237/14 , A61K31/50 , C07D231/14
CPC分类号： C07D471/04 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/50 , A61K31/505 , A61K31/5377 , C07C281/02 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/40 , C07D237/14 , C07D237/24 , C07D239/28 , C07D239/34 , C07D239/36 , C07D239/52 , C07D239/54 , C07D249/04 , C07D249/10 , C07D249/12 , C07D249/18 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/32 , C07D263/34 , C07D263/38 , C07D277/34 , C07D277/56 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/04 , Y02P20/55
摘要： In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
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