公开(公告)号：US20160341687A1

公开(公告)日：2016-11-24

申请号：US15115033

申请日：2015-01-29

Applicant: David A. WALL ,  STC.UNM

Inventor： Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

IPC: G01N27/327 ,  G01N33/543

CPC classification number: G01N27/3273 ,  G01N27/3276 ,  G01N33/5438

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.

Abstract translation: 本公开在一个方面描述了一种用于自身抗体的电化学定量的装置。 通常，该装置包括限定多个通道和至少两个反应区的外壳。 第一反应区包括多孔膜和与第一通道流体连通的第一电极组件。 第一反应区还包括固定在多孔膜上的第一组多个自身抗原。 第一电极组件与电流读数器连通。 第二反应区包括多孔膜和与第二通道流体连通的第二电极组件。 第二反应区包括固定在多孔膜上的第二多个自身抗原。 第二电极组件与电流读数器连通。 最后，该装置包括与第一反应区和第二反应区流体连通的负压源。

公开(公告)号：US10794852B2

公开(公告)日：2020-10-06

申请号：US15115033

申请日：2015-01-29

Applicant: STC.UNM ,  Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

Inventor： Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

IPC: G01N27/327 ,  G01N33/543

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.