公开(公告)号：US10794852B2

公开(公告)日：2020-10-06

申请号：US15115033

申请日：2015-01-29

Applicant: STC.UNM ,  Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

Inventor： Robert L. Rubin ,  Konstantin N. Konstantinov ,  David A. Wall

IPC: G01N27/327 ,  G01N33/543

Abstract: This disclosure describes, in one aspect, a device for electrochemical quantitation of autoantibodies. Generally, the device includes a housing that defines a plurality of channels and at least two reaction zones. A first reaction zone includes a porous membrane and a first electrode assembly in fluid communication with a first channel. The first reaction zone also includes a first plurality of autoantigens immobilized to the porous membrane. The first electrode assembly is in communication with an amperometric reader. A second reaction zone includes a porous membrane and a second electrode assembly in fluid communication with a second channel. The second reaction zone includes a second plurality of autoantigens immobilized to the porous membrane. The second electrode assembly is in communication with the amperometric reader. Finally, the device includes a source of negative pressure in fluid communication with the first reaction zone and the second reaction zone.