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    Synthetic biofilm-inhibiting peptides
    1.
    发明授权
    Synthetic biofilm-inhibiting peptides 有权
    合成生物膜抑制肽

    公开(公告)号：US08142764B2

    公开(公告)日：2012-03-27

    申请号：US12392966

    申请日：2009-02-25

    申请人： Donald R. Demuth ,  Carlo Amorin Daep

    发明人： Donald R. Demuth ,  Carlo Amorin Daep

    IPC分类号： A61K38/10 ,  A61K38/16 ,  A61Q11/00 ,  C07K7/08 ,  C07K14/00

    CPC分类号： C07K14/315 ,  A23L33/18 ,  A61K8/64 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/4866 ,  A61K38/00 ,  A61K2800/86 ,  A61Q11/00 ,  Y10S514/835

    摘要： The present invention provides streptococcal SspB Adherence Region (BAR) peptides consisting of Formula I: R18-R1- R2-Val-R3-R4-Leu-Leu-R5-R6-R7-Ile-R8-R9-Lys-R10-R19 , wherein R2, is 1-3 Lys residues; R3 is any amino acid residue except a Pro residue; R4 is any amino acid residue except a Pro residue; R5 is 1-3 Lys residues; R6 is 1-10 amino acid residues; R7 is any amino acid residue except Asp, Glu, Gly or Pro; R8 is any amino acid residue except Ala, Asp, Gly, His, Ile, Pro, Trp or Tyr; R9 is a Val, Ile, Phe, or Trp residue; R10 is 0-1 Cys residue; R18 is 0 amino acids or R12-R11-Pro-, wherein R11 is 0-3 amino acids, wherein the amino acid residues are not Gly or Pro; and R12 is 0-1 Cys residues; and R19 is R13-R14-R15-R16-R17, wherein R13 is 0-1 is Gly residue; R14 is 0-1 Ala residue; R15 is 0-1 Phe residue; R16 is 0-1 Gln residue; R17 is 0-1 Cys residue; and wherein R1 is an ornithine residue; or wherein both R1 and R10 are both Cys and R1 and R10 are covalently linked to form a circular peptide; or wherein R1 is 0-1 Cys or an ornithine residue and R12 and R17, are both Cys and R12 and R17 are covalently linked to form a circular peptide. Embodiments of the present invention further provide devices coated with the BAR peptides.

    摘要翻译： 本发明提供由式I：R18-R1-R2-Val-R3-R4-Leu-Leu-R5-R6-R7-I-R8-R9-Lys-R10-R19组成的链球菌SspB依赖区（BAR）肽 其中R2为1-3个Lys残基; R3是除Pro残基外的任何氨基酸残基; R4是除Pro残基外的任何氨基酸残基; R5为1-3个Lys残基; R6为1-10个氨基酸残基; R7是除Asp，Glu，Gly或Pro之外的任何氨基酸残基; R8是除Ala，Asp，Gly，His，Ile，Pro，Trp或Tyr之外的任何氨基酸残基; R9是Val，Ile，Phe或Trp残基; R10为0-1个Cys残基; R18为0个氨基酸或R12-R11-Pro-，其中R11为0-3个氨基酸，其中氨基酸残基不是Gly或Pro; R12为0-1个Cys残基; R19为R13-R14-R15-R16-R17，其中R13为0-1为Gly残基; R14为0-1个Ala残基; R15为0-1 Phe残基; R16为0-1 Gln残基; R17为0-1个Cys残基; 并且其中R1是鸟氨酸残基; 或其中R 1和R 10均为Cys且R 1和R 10共价连接以形成环状肽; 或其中R1为0-1Cys或鸟氨酸残基，R12和R17均为Cys和R12，R17共价连接形成环状肽。 本发明的实施方案还提供了涂覆有BAR肽的装置。