公开(公告)号：US20030008300A1

公开(公告)日：2003-01-09

申请号：US10045603

申请日：2001-10-23

Applicant: Duke University

Inventor： Jonathan S. Stamler ,  Joseph Bonaventura ,  John R. Pawloski ,  Timothy J. McMahon

IPC: C12Q001/68

CPC classification number: A61K31/00 ,  A61K31/04 ,  A61K31/095 ,  A61K31/195 ,  A61K33/00 ,  A61K38/1816 ,  A61K47/54 ,  A61K47/6445 ,  A61K47/6901 ,  C07K14/00 ,  G01N21/631 ,  G01N21/76 ,  G01N33/721

Abstract: Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NOnull groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.

Abstract translation: 红细胞可以装载低分子量亚硝酰化剂，如S-亚硝基硫醇，作为NO +组组织的递送系统。 加载的红细胞可用于以组织异常氧代谢，氧相关毒性，异常血管紧张，红细胞异常粘附或红细胞异常氧传递为特征的病症的治疗方法。 红细胞的这种治疗可以延伸到体内治疗，其目的是实现红细胞S-亚硝基硫醇与血红蛋白的比例的增加。