公开(公告)号：US11590109B2

公开(公告)日：2023-02-28

申请号：US16306465

申请日：2017-06-02

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  INSTITUT PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES

Inventor： Ke Xu ,  Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Lili Zhu ,  Wenlin Song ,  Yi Tong

IPC: A61K31/426 ,  A61P31/12 ,  C07D277/50

Abstract: Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:

公开(公告)号：US10919869B2

公开(公告)日：2021-02-16

申请号：US16302564

申请日：2017-05-17

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin Li ,  Yufang Xu ,  Rui Wang ,  Zhenjiang Zhao ,  Wenlin Song ,  Liuxin Xu

IPC: C07D277/50 ,  A61P19/02 ,  A61P37/00 ,  A61P33/00 ,  A61K31/426 ,  A61P35/00 ,  A61P17/06 ,  A61P31/04

Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.