公开(公告)号：US20240335591A1

公开(公告)日：2024-10-10

申请号：US18747769

申请日：2024-06-19

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tara J. Tod

IPC: A61L27/36 ,  A61L17/08 ,  A61L27/24 ,  A61L27/50 ,  A61L27/58

CPC classification number: A61L27/3691 ,  A61L17/08 ,  A61L27/24 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/507 ,  A61L27/58 ,  A61L2430/20

Abstract: Methods of manufacturing collagen fibers comprising any one, a combination or all of the following: at least partially decellularizing a collagenous tissue; homogenizing the collagenous tissue; separating at least a portion of collagen fibers from the collagenous tissue; exposing the collagen fibers to an acidic solution before or after the separating; and forming at least one of a suture, a woven structure, a knitted structure, or a bioprosthetic device with the collagen fibers.

公开(公告)号：US12023416B2

公开(公告)日：2024-07-02

申请号：US16695042

申请日：2019-11-25

Applicant: Edwards Lifesciences Corporation

Inventor： Tara J. Tod

IPC: A61L27/24 ,  A61L17/08 ,  A61L27/36 ,  A61L27/50 ,  A61L27/58

CPC classification number: A61L27/3691 ,  A61L17/08 ,  A61L27/24 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/507 ,  A61L27/58 ,  A61L2430/20

Abstract: Methods of manufacturing collagen fibers comprising any one, a combination or all of the following: at least partially decellularizing a collagenous tissue; homogenizing the collagenous tissue; separating at least a portion of collagen fibers from the collagenous tissue; exposing the collagen fibers to an acidic solution before or after the separating; and forming at least one of a suture, a woven structure, a knitted structure, or a bioprosthetic device with the collagen fibers.

公开(公告)号：US20230248512A1

公开(公告)日：2023-08-10

申请号：US18301176

申请日：2023-04-14

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tara J. Tod ,  Mark Van Nest ,  Kiem Bao Nguyen ,  Liqiong Gui ,  Lien Huong Thi Hoang ,  Son V. Nguyen ,  Hao Shang

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2250/0098

Abstract: Devices and methods for reinforcing a tissue-based heart valve are provided. A reinforced tissue valve can provide structure and rigidity to withstand stresses that occur within the vasculature. In some instances, thickened tissue provides structure or rigidity. In some instances, a biocompatible filler is utilized within folded, rolled, or layered tissue. In some instances, a mesh is included with a reinforced tissue valve for further strength. In some instances, a mesh frame is utilized along the sidewall of a tissue-based heart valve. In some instances, a leaflet assembly is provided within a conduit having thickened tissue at the leaflet commissures.

公开(公告)号：US20210100931A1

公开(公告)日：2021-04-08

申请号：US17127281

申请日：2020-12-18

Applicant: Edwards Lifesciences Corporation

Inventor： Jeffrey S. Dove ,  Tara J. Tod

IPC: A61L27/36 ,  A61L27/54 ,  A61L27/50

Abstract: Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.

公开(公告)号：US20200171205A1

公开(公告)日：2020-06-04

申请号：US16695042

申请日：2019-11-25

Applicant: Edwards Lifesciences Corporation

Inventor： Tara J. Tod

IPC: A61L27/36 ,  A61L27/50 ,  A61L27/24 ,  A61L17/08

Abstract: Methods of manufacturing collagen fibers comprising any one, a combination or all of the following: at least partially decellularizing a collagenous tissue; homogenizing the collagenous tissue; separating at least a portion of collagen fibers from the collagenous tissue; exposing the collagen fibers to an acidic solution before or after the separating; and forming at least one of a suture, a woven structure, a knitted structure, or a bioprosthetic device with the collagen fibers.

公开(公告)号：US12115280B2

公开(公告)日：2024-10-15

申请号：US17127281

申请日：2020-12-18

Applicant: Edwards Lifesciences Corporation

Inventor： Jeffrey S. Dove ,  Tara J. Tod

IPC: A61L27/36 ,  A61L27/50 ,  A61L27/54

CPC classification number: A61L27/3687 ,  A61L27/50 ,  A61L27/54 ,  A61L2430/20 ,  A61L2430/40

Abstract: Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.