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1.发明授权公开(公告)号：US12115280B2
公开(公告)日：2024-10-15
申请号：US17127281
申请日：2020-12-18
发明人： Jeffrey S. Dove , Tara J. Tod
CPC分类号： A61L27/3687 , A61L27/50 , A61L27/54 , A61L2430/20 , A61L2430/40
摘要： Methods are provided herein for modifying antigenic carbohydrate epitopes within a xenographic bioprosthetic tissue by oxidation of vicinal diols to form aldehydes or acids and subsequence reductive amination of aldehydes to form stable secondary amines, or amidation or esterification of acids to form stable amides or esters. Advantageously, methods provided herein mitigate the antigenicity of the bioprosthetic tissue while leaving the overall tissue structure substantially undisturbed, and thereby enhance the durability, safety and performance of the bioprosthetic implant.
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公开(公告)号：US12064532B2
公开(公告)日：2024-08-20
申请号：US17872467
申请日：2022-07-25
CPC分类号： A61L27/3804 , A61L27/3604 , A61L27/3687 , A61L27/3691 , A61L27/52 , C12N5/0609 , A61L2400/06 , A61L2430/40 , C12N2500/84
摘要： The present invention relates to an ovarian-derived hydrogel material, which can be useful for three-dimensional in vitro culturing of cells, cell therapy, fertility preservation, drug delivery, site-specific remodeling and repair of damaged tissue, and/or diagnostic kits.
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公开(公告)号：US20240252722A1
公开(公告)日：2024-08-01
申请号：US18602785
申请日：2024-03-12
申请人： Telea Biotech S.R.L.
CPC分类号： A61L27/3691 , A61L27/3679 , A61L27/38 , A61L2430/22 , A61L2430/40
摘要： A device adapted to make one or more holes on a surface of a biocompatible tissue for revitalizing the tissue, the device including one or more conductive needles arranged on a mechanical stand, the mechanical stand having a support that mainly extends along a longitudinal extension axis configured to be introduced into a cavity defined by an essentially tubular-shaped biocompatible tissue, the one or more conductive needles being directed towards an outer and/or inner surface of the support such as to make one or more holes spread out on at least one generatrixes of the tissue, the one or more holes being made with a depth which occupies at least a part of a thickness of the tissue.
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公开(公告)号：US20240238481A1
公开(公告)日：2024-07-18
申请号：US18439809
申请日：2024-02-13
申请人： GLOBUS MEDICAL, INC.
发明人： Joshua Cige , Archana Bhat , Joanna Marquez
CPC分类号： A61L27/3608 , A61L27/3616 , A61L27/365 , A61L27/3683 , A61L27/56 , A61L2430/02 , A61L2430/40
摘要： Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may include demineralized cortical fibers, which help to promote bone repair.
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公开(公告)号：US12023417B2
公开(公告)日：2024-07-02
申请号：US16933866
申请日：2020-07-20
发明人： David Maimon , Tamir S. Levi , Elena Sherman
CPC分类号： A61L27/3691 , A61F2/2415 , A61L27/3625 , A61L27/3641 , B29C55/02 , A61F2240/001 , A61L2430/20 , A61L2430/40 , B29K2995/0056 , B29L2031/7534
摘要： A method is provided for pre-stretching implantable biocompatible materials, such as material to be incorporated into an implantable device. A sheet of implantable biocompatible material is attached to one or more tensioning members, where tension is applied along one or more axes. Tension is applied for a period of time, and at an appropriate force, to produce a desired degree of thinning or pre-stretching of the implantable biocompatible material. During the tensioning, the implantable biocompatible material is maintained at an elevated temperature, such as a temperature that is at least substantially a temperature of an environment into which the material will be implanted.
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公开(公告)号：US20240207488A1
公开(公告)日：2024-06-27
申请号：US18386832
申请日：2023-11-03
申请人： LifeCell Corporation
发明人： Wendell Sun , Jerome Connor , Qing-Qing Qiu , Rick T. Owens
CPC分类号： A61L27/505 , A01N1/0226 , A61L2/08 , A61L27/36 , A61L27/362 , A61L27/3683 , A61L2430/40
摘要： The present disclosure provides a variety of methods and compositions e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).
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公开(公告)号：US20240131230A1
公开(公告)日：2024-04-25
申请号：US18277243
申请日：2021-02-15
申请人： L&C BIO Co., Ltd.
发明人： Sol LEE , Ki Min KIM , Sang Yeol KIM , Kwang Hoon SHIN , Hyun Seung LEE , Hyung Gu KIM , Whan Chul LEE
CPC分类号： A61L27/60 , A61F2/12 , A61L27/362 , A61L27/3687 , A61L27/3691 , A61F2220/0075 , A61F2230/0006 , A61F2230/0023 , A61F2240/001 , A61L2430/04 , A61L2430/40
摘要： The present invention relates to an acellular skin substitute for breast reconstruction and a preparation method therefor.
In the present invention, an acellular skin substitute may be prepared through the removal of epidermal layers and an acellularization process, in which the use of a proteolytic enzyme and a surfactant is excluded. In addition, since the acellular skin substitute is cut into suitable sizes and shapes to cover a breast reconstruction implant through design software and then cut out with a CNC machine, the time for breast reconstruction surgery may be reduced, and since no dead space is formed after suturing, the incidence of seromas may be reduced. Accordingly, the side effects of surgery may be lessened.-
公开(公告)号：US11963869B2
公开(公告)日：2024-04-23
申请号：US17456075
申请日：2021-11-22
CPC分类号： A61F2/2418 , A61F2/0095 , A61F2/06 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2427 , A61L27/222 , A61L27/24 , A61L27/3625 , A61L27/3687 , A61L27/507 , A61F2210/0004 , A61F2220/0075 , A61F2310/00371 , A61F2310/00383 , A61L2430/20 , A61L2430/40
摘要： A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.
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公开(公告)号：US11951233B2
公开(公告)日：2024-04-09
申请号：US17251790
申请日：2019-09-11
发明人： Dar-Jen Hsieh , Chao-Yi Wei , Chao-Chin Chao , Jer-Cheng Kuo , Yi-Ping Lai , Srinivasan Periasamy
CPC分类号： A61L27/3691 , A61L27/3625 , A61L27/3687 , A61L2430/20 , A61L2430/40
摘要： Provided are methods of producing an acellular organ. The method includes the steps of, subjecting an organ derived from an animal to a static supercritical fluid (SCF) treatment followed by a dynamic SCF treatment. Optionally, the method of the present disclosure further includes a hypertonic and a hypotonic treatments prior to the static SCF treatment, and/or a neutralizing treatment after the dynamic SCF treatment. Also disclosed herein are acellular organs produced by the present method.
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公开(公告)号：US11944532B2
公开(公告)日：2024-04-02
申请号：US18062738
申请日：2022-12-07
CPC分类号： A61F2/0811 , A61F2/08 , A61K35/32 , A61L27/3662 , A61L27/3687 , A61L27/3834 , A61L27/386 , C12N5/066 , C12N5/0669 , A61F2/0095 , A61F2002/087 , A61F2220/0008 , A61F2240/001 , A61F2250/0067 , A61L2430/10 , A61L2430/40 , C12N2500/33 , C12N2501/115 , C12N2501/999 , C12N2513/00
摘要： The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.
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