公开(公告)号：US09889969B2

公开(公告)日：2018-02-13

申请号：US14282831

申请日：2014-05-20

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  David DeCoste

IPC: G06K19/06 ,  B65D25/20 ,  B65D75/56 ,  B65D75/58 ,  G06K7/10 ,  B31D1/02 ,  B65D33/00 ,  B31B50/81

CPC classification number: B65D25/205 ,  B31B50/81 ,  B31D1/028 ,  B65D33/004 ,  B65D75/566 ,  B65D75/5877 ,  B65D2203/10 ,  G06K7/10237 ,  Y10T29/49016 ,  Y10T156/10

Abstract: The present invention provides a process for incorporating a wireless device into a plastic container as part of the steps of manufacturing the container. The plastic container can be a flexible plastic bag and are formed of one or more sheets, generally two or more sheets of plastic film or a rigid plastic container such as a tub or tote. The bags are formed by sealing together adjacent edge portions of each film layer. One embodiment of the present invention is to incorporate a wireless device between the edge portions of the film(s) before or during sealing so that the wireless device becomes permanently sealed into the film material but is isolated from both the bag interior and the outside environment. Another embodiment is to incorporate the wireless device onto or into a plastic component that is sealed to the container, such as a nipple or port, so that the wireless device becomes permanently sealed to the container but is isolated from both the container interior and the outside environment.

公开(公告)号：US09046292B2

公开(公告)日：2015-06-02

申请号：US13654595

申请日：2012-10-18

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: F25D25/00 ,  F25D21/00 ,  F25D3/08 ,  F25B49/00 ,  F25D29/00 ,  A01N1/02

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。

公开(公告)号：US09027356B2

公开(公告)日：2015-05-12

申请号：US13654593

申请日：2012-10-18

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: F25D25/00 ,  F25D21/00 ,  F25D3/08 ,  F25B49/00 ,  F25D29/00 ,  A01N1/02

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

公开(公告)号：US20130312492A1

公开(公告)日：2013-11-28

申请号：US13956428

申请日：2013-08-01

Applicant: EMD Millipore Corporation

Inventor： Brian Hillier ,  Martin Szyk ,  Aaron Burke ,  Joseph Almasian

IPC: G01N15/08

CPC classification number: F16K31/50 ,  F16K1/12 ,  F16K11/22 ,  F16K31/445 ,  F16K31/60 ,  G01N15/0826 ,  Y10T137/0318 ,  Y10T137/7932 ,  Y10T137/794 ,  Y10T137/85938 ,  Y10T137/87885

Abstract: Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position.

Abstract translation: 流体输送装置包括具有通过其内部的至少一部分形成的孔的主体。 包含在孔内的是可移动的柱塞，其移动而不改变主体的轴向尺寸。 身体的第一端包含设计成连接到上游部件的面。 主体的第二端连接到诸如过滤器，管道等的下游部件。当处于关闭位置时，柱塞的第一端与主体的表面对准，其结合形成一个 可蒸发的表面和抵抗环境的无菌屏障到身体内部的其余部分，柱塞和下游部件。 外环形套环可相对于主体旋转并使柱塞在孔内轴向移动，从开放到闭合位置。

公开(公告)号：US20130306897A1

公开(公告)日：2013-11-21

申请号：US13955309

申请日：2013-07-31

Applicant: EMD Millipore Corporation

Inventor： Brian Hillier ,  Martin Szyk ,  Aaron Burke ,  Joseph Almasian

IPC: F16K31/44 ,  F16K11/22 ,  F16K31/60

CPC classification number: F16K31/50 ,  F16K1/12 ,  F16K11/22 ,  F16K31/445 ,  F16K31/60 ,  G01N15/0826 ,  Y10T137/0318 ,  Y10T137/7932 ,  Y10T137/794 ,  Y10T137/85938 ,  Y10T137/87885

Abstract: Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position.

公开(公告)号：US10138023B2

公开(公告)日：2018-11-27

申请号：US15860146

申请日：2018-01-02

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  David DeCoste

IPC: G06K19/06 ,  B65D25/20 ,  B65D75/56 ,  B65D75/58 ,  G06K7/10 ,  B31D1/02 ,  B65D33/00 ,  B31B50/81

Abstract: The present invention provides a process for incorporating a wireless device into a plastic container as part of the steps of manufacturing the container. The plastic container can be a flexible plastic bag and are formed of one or more sheets, generally two or more sheets of plastic film or a rigid plastic container such as a tub or tote. The bags are formed by sealing together adjacent edge portions of each film layer. One embodiment of the present invention is to incorporate a wireless device between the edge portions of the film(s) before or during sealing so that the wireless device becomes permanently sealed into the film material but is isolated from both the bag interior and the outside environment. Another embodiment is to incorporate the wireless device onto or into a plastic component that is sealed to the container, such as a nipple or port, so that the wireless device becomes permanently sealed to the container but is isolated from both the container interior and the outside environment.

公开(公告)号：US20140320268A1

公开(公告)日：2014-10-30

申请号：US14328410

申请日：2014-07-10

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke

IPC: G06K7/10

CPC classification number: G06K7/10366 ,  A61L2/26 ,  G06K19/0717 ,  G06K19/0723

Abstract: A system and method for verifying the occurrence of an environmental condition is disclosed. Rather than store information concerning the occurrence and/or success of the sterilization process, the present invention modifies the wireless transmission characteristics of the device. In some embodiments, the bandwidth of the wireless transceiver is altered as a result of undergoing sterilization. In other embodiments, the resonance frequency of the circuit is affected. In other embodiments, one or more of these parameters are affected based on other environmental conditions, such as shock or vibration.

Abstract translation: 公开了一种用于验证环境条件的发生的系统和方法。 本发明不是存储关于灭菌处理的发生和/或成功的信息，而是修改设备的无线传输特性。 在一些实施例中，作为进行灭菌的结果，无线收发器的带宽被改变。 在其他实施例中，电路的谐振频率受到影响。 在其他实施例中，这些参数中的一个或多个基于其他环境条件（例如冲击或振动）而受到影响。

公开(公告)号：US20140073040A1

公开(公告)日：2014-03-13

申请号：US14080466

申请日：2013-11-14

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke

IPC: C12M1/12

CPC classification number: C12M37/02 ,  A61L2/26 ,  B01D63/00 ,  C12M23/14 ,  C12M29/00 ,  C12M41/00 ,  G01L19/0645

Abstract: A system and method for interfacing non-sterile sensors to a sterile flow stream is disclosed. Typically, sensors cannot be sterilized in the same manner as other components of the flow stream. This results in complex processes to incorporate a sterilized sensor into a sterilized flow stream. By introducing a separation membrane, the desired sensor can be interfaced to the sterile flow stream. By doing so, the sensor need not be sterile, only sufficiently clean. The membrane separates the sterile environment within the flow stream from the sensor, while still permitting the sensor to function.

Abstract translation: 公开了一种用于将非无菌传感器与无菌流动流接口的系统和方法。 通常，传感器不能以与流动流的其它部件相同的方式灭菌。 这导致复杂的过程将消毒的传感器并入灭菌的流动流中。 通过引入分离膜，期望的传感器可以与无菌流动流相连。 通过这样做，传感器不需要无菌，只能充分清洁。 膜将来自传感器的流动中的无菌环境分开，同时仍允许传感器起作用。

公开(公告)号：US20140091020A1

公开(公告)日：2014-04-03

申请号：US14053891

申请日：2013-10-15

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Anthony DiLeo ,  Timothy O'Brien

IPC: B01D65/02

CPC classification number: B01D53/22 ,  B01D61/22 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/103 ,  B01D2311/16 ,  B01D2313/22 ,  B01D2321/40 ,  G01F1/6888 ,  G01F1/69 ,  G01F15/125

Abstract: An autonomous filter device and a method for improving the filter life and performance is disclosed. The filter element is equipped with one or more sensors, adapted to measure one or more characteristics. In response to the measured characteristic, the control logic within the filter element is able to determine an appropriate response. For example, the control logic may determine that a sudden, but temporary, blockage has occurred in the filter membrane. In response, the control logic may initiate a specific response designed to alleviate the blockage. The control logic will then determine the success of the response, based monitoring any change in the fluid characteristics. Based thereon, the control logic may alert the operator that the filter element must be replaced. Alternatively, if the response was successful in correcting the blockage, the control logic need not notify the operator, as the filter element is back to normal operating operation.

Abstract translation: 公开了一种自主的过滤装置和改善过滤器寿命和性能的方法。 过滤器元件配备有适于测量一个或多个特性的一个或多个传感器。 响应于测量的特性，滤波器元件内的控制逻辑能够确定适当的响应。 例如，控制逻辑可以确定在过滤膜中已经发生突然而暂时的堵塞。 作为响应，控制逻辑可以启动旨在减轻阻塞的特定响应。 然后，控制逻辑将确定响应的成功，基于监测流体特性的任何变化。 基于此，控制逻辑可以警告操作者必须更换过滤元件。 或者，如果响应成功地纠正堵塞，则控制逻辑不需要通知操作者，因为过滤器元件已经回到正常的操作操作。

公开(公告)号：US20130039382A1

公开(公告)日：2013-02-14

申请号：US13654595

申请日：2012-10-18

Applicant: EMD Millipore Corporation

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: G01N25/00

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。