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    Stable extract from Hypericum perforatum L., method for the production thereof and its use as a topical medicament
    1.
    发明授权
    Stable extract from Hypericum perforatum L., method for the production thereof and its use as a topical medicament 有权
    来自金丝桃的稳定提取物，其生产方法及其作为局部药物的用途

    公开(公告)号：US07166310B2

    公开(公告)日：2007-01-23

    申请号：US10451714

    申请日：2001-12-21

    申请人： Egon Koch ,  Clemens Erdelmeier ,  Joachim Herrmann

    发明人： Egon Koch ,  Clemens Erdelmeier ,  Joachim Herrmann

    IPC分类号： A61K36/38 ,  A61K33/04

    CPC分类号： A61K36/38 ,  C07C45/78 ,  C07C49/743

    摘要： The invention relates to an improved and stable (i.e. color-stable and, optionally, stable with regard to its hyperforin content) extract from the overground parts of Hypericum perforatum L., to a method for the preparation thereof, and to pharmaceutical preparations and topical medicaments that contain this extract; in particular, gels for treating skin and mucous membrane irritations and disorders such as acne, atopic dermatitis, neuro-dermatitis, psoriasis, stomatitis, herpes zoster, herpes labialis (lip herpes), warts, varicella (chicken-pox), sores, burns and other bacterial and viral skin and mucous membrane infections and skin disorders that are accompanied by cell proliferation and inflammation.

    摘要翻译： 本发明涉及从贯叶连翘的地上部分提取物，其制备方法以及药物制剂和局部施用的改进和稳定（即，其稳定性，并且可选地稳定于其高福林含量） 含有此提取物的药物; 特别是用于治疗皮肤和粘膜刺激的凝胶和诸如痤疮，特应性皮炎，神经性皮炎，牛皮癣，口腔炎，带状疱疹，唇疱疹（唇疱疹），疣，水痘（鸡痘），疮，烧伤的疾病 以及伴随细胞增殖和炎症的其它细菌和病毒皮肤和粘膜感染和皮肤病症。

    Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones
    3.
    发明申请
    Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones 审中-公开
    制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法

    公开(公告)号：US20060251746A1

    公开(公告)日：2006-11-09

    申请号：US11416924

    申请日：2006-05-02

    申请人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    发明人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    IPC分类号： A61K36/16

    CPC分类号： A61K36/16 ,  A23L33/11

    摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

    摘要翻译： 本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或 离子交换剂和待除去的物质保留在树脂上。 本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

    Method for preparing ginkgo extracts having a low content of 4′-O-methyl pyridoxine and/or biflavones
    4.
    发明授权
    Method for preparing ginkgo extracts having a low content of 4′-O-methyl pyridoxine and/or biflavones 有权
    制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法

    公开(公告)号：US08642099B2

    公开(公告)日：2014-02-04

    申请号：US12217803

    申请日：2008-07-09

    申请人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    发明人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    IPC分类号： A61K35/16

    CPC分类号： A61K36/16 ,  A23L33/11

    摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

    摘要翻译： 本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或 离子交换剂和待除去的物质保留在树脂上。 本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

    Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones
    5.
    发明申请
    Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones 有权
    制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法

    公开(公告)号：US20080286391A1

    公开(公告)日：2008-11-20

    申请号：US12217803

    申请日：2008-07-09

    申请人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    发明人： Clemens Erdelmeier ,  Hermann Hauer ,  Egon Koch ,  Friedrich Lang

    IPC分类号： A61K36/16 ,  A61P25/00

    CPC分类号： A61K36/16 ,  A23L33/11

    摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

    摘要翻译： 本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或 离子交换剂和待除去的物质保留在树脂上。 本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

    Method for preparing a Ginkgo extract having a reduced content of 4'-O-methyl pyridoxine and/or biflavones
    7.
    发明申请
    Method for preparing a Ginkgo extract having a reduced content of 4'-O-methyl pyridoxine and/or biflavones 审中-公开
    制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的方法

    公开(公告)号：US20060251745A1

    公开(公告)日：2006-11-09

    申请号：US11416878

    申请日：2006-05-02

    申请人： Clemens Erdelmeier ,  Egon Koch ,  Karl-Heinz Stumpf ,  Hermann Hauer ,  Friedrich Lang

    发明人： Clemens Erdelmeier ,  Egon Koch ,  Karl-Heinz Stumpf ,  Hermann Hauer ,  Friedrich Lang

    IPC分类号： A61K36/16

    CPC分类号： A61K36/16 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/2122 ,  A23V2200/326

    摘要： The present invention relates to a method for preparing an extract from Ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones compared to the original extract. The invention further relates to extracts from Ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones compared to the original extract, which is obtainable by the method according to the present invention, as well as to their use.

    摘要翻译： 制备具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏的提取物包括（a）在溶剂中制备银杏提取物溶液; （b）将溶液施加到吸附树脂上并从吸附树脂中洗脱纯化的提取物; 和/或（c）将溶液施加到酸性离子交换剂上并从离子交换剂洗脱纯化的提取物; 并且任选地（d）将提取液浓缩并干燥到干提取物中，其中步骤（b）和（c）可以以相反的顺序进行。 与原始提取物相比，制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏的提取物包括：（a）在溶剂中制备银杏提取物溶液; （b）将溶液施加到吸附树脂上，并使用溶剂从吸附树脂中洗脱纯化的提取物，其中双黄酮保留在吸附树脂上; 和/或（c）将溶液施加到酸性离子交换剂上，并使用溶剂从离子交换器中洗脱纯化的提取物，其中4'-O-甲基吡哆醛保留在离子交换剂上; 和（d）任选地将提取液浓缩并干燥到干提取物中，其中步骤（b）和（c）可以以相反的顺序进行。 与原始提取物相比，具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物的独立权利要求。 - 活动：灵巧。 - 行动机制：没有给出。

    Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease
    8.
    发明授权
    Stable hyperforin salts, method for producing same and their use in the treatment of alzheimer's disease 失效
    稳定的高福林盐，其制备方法及其在治疗阿尔茨海默氏病中的应用

    公开(公告)号：US06444662B1

    公开(公告)日：2002-09-03

    申请号：US09622151

    申请日：2000-08-11

    申请人： Shyam Sunder Chatterjee ,  Clemens Erdelmeier ,  Klaus Klessing ,  Dieter Marme ,  Christoph Schächtele

    发明人： Shyam Sunder Chatterjee ,  Clemens Erdelmeier ,  Klaus Klessing ,  Dieter Marme ,  Christoph Schächtele

    IPC分类号： C07C5036

    CPC分类号： C07C49/743 ,  C07C45/78

    摘要： Described are salts of hyperforin and adhyperforin of formula I [A−]m[B]p+  (I) wherein m is an integer from 1 to 3, p is equal to m and gives the total number of positive charges of the residue [B], [A−] is an anion of formula II with n=0 or 1 and [B]p+ is an ion of an alkali metal or an ammonium ion of a salt-forming nitrogen base of formula III wherein R1 through R4 have a variety of meanings including hydrogen, alkyl, cycloalkyl and similar groups which in turn may be substituted with one or more substituents. The salts serve inter alia for enriching or purifying hyperforin and adhyperforin from St. John's Wort extracts. Pharmaceutical preparations containing the salts are used for treating Alzheimer's Disease.

    摘要翻译： 描述了式I的高效蛋白和高血压素的盐，其中m是1至3的整数，p等于m并且给出残基[B]的正电荷的总数，[A-]是式II的阴离子， n = 0或1，[B] p +是式III的形成盐的氮碱的碱金属或铵离子的离子，其中R1至R4具有各种含义，包括氢，烷基，环烷基和类似基团， 可以被一个或多个取代基取代。 这些盐特别用于从圣约翰草提取物中富集或纯化高效蛋白和高血压素。 含有盐的药物制剂用于治疗阿尔茨海默病。