公开(公告)号：US20170065192A1

公开(公告)日：2017-03-09

申请号：US15355616

申请日：2016-11-18

Applicant: Empire Technology Development LLC

Inventor： Himanshu MISHRA ,  Mona SHARMA ,  Mandar SHIRISH DIXIT

IPC: A61B5/03 ,  A61K9/48 ,  G01N33/493 ,  A61K47/32 ,  A61K47/38 ,  A61K9/00 ,  A61K9/20

CPC classification number: A61B5/03 ,  A61B5/4255 ,  A61B2562/0247 ,  A61B2562/162 ,  A61K9/0053 ,  A61K9/2072 ,  A61K9/4816 ,  A61K9/4825 ,  A61K9/4833 ,  A61K9/4866 ,  A61K9/4891 ,  A61K47/32 ,  A61K47/38 ,  G01L1/00 ,  G01L7/102 ,  G01L7/106 ,  G01M3/02 ,  G01N33/493

Abstract: A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

Abstract translation: 公开了压力检测片。 片剂是一种胶囊，其包括封装在内部涂层内的染料，其中内部涂层被配置为在等于或大于压力阈值的压力下破裂。 片剂还包括围绕胶囊的外涂层，其中外涂层被配置为提供胶囊到目标部位的输送。 染料可以是非代谢的水溶性染料，使得破裂的胶囊释放可以在尿液中目视检测的染料。 在一些实施方案中，本公开提供了使用片剂检测结肠中的峰值压力并降低发生结肠疾病风险的制备片剂的方法。