公开(公告)号：US12191133B2

公开(公告)日：2025-01-07

申请号：US17610010

申请日：2020-05-08

Applicant: ORVINUM AG

Inventor： Frank Jochen Dieterle ,  Timm Fabian Manfred Hettich ,  Christian Berchtold ,  Gotz Schlotterbeck ,  Markus Ehrat

IPC: H01J49/36 ,  H01J49/00 ,  H01J49/16 ,  G01N33/14 ,  G01N33/483 ,  G01N33/49 ,  G01N33/493

Abstract: The present invention relates to a method for identifying and/or authenticating a sample, comprising adding at least one chemical compound to the sample, determining a level of the at least one compound after addition to the sample; comparing the level of the at least one compound to a reference level and identifying the sample based on the comparison with the reference sample and the effect of the sample on the level of the at least one compound. The invention further relates to the use of the at least one compound in the method for identifying and/or authenticating a sample. Further, the invention relates to the use of a kit comprising the at least one compound in the inventive method. In addition, the invention relates to a composition comprising the at least one compound. Further, the invention relates to a kit comprising the compositions provided herein, e.g. for calibrating the methods provided herein and/or the instruments employed in the methods provided herein.

公开(公告)号：US20240426840A1

公开(公告)日：2024-12-26

申请号：US18747285

申请日：2024-06-18

Applicant: The Texas A&M University System

Inventor： Jessica A. Hokamp ,  Mary B. Nabity

IPC: G01N33/68 ,  A61K31/192 ,  A61K31/5377 ,  A61K31/573 ,  A61K38/13 ,  A61K45/06 ,  G01N27/447 ,  G01N33/493

Abstract: Disclosed are methods and compositions for detecting glomerular disease in dogs and effectively treating dogs with glomerular diseases such as membranoproliferative immune complex-mediated glomerulonephritis (MPGN). Methods and compositions for detecting glomerular or tubular damage in cats and effectively treating cats with glomerular or tubular damage are also provided.

公开(公告)号：US12055535B2

公开(公告)日：2024-08-06

申请号：US16781409

申请日：2020-02-04

Applicant: The Cleveland Clinic Foundation

Inventor： Stanley L. Hazen ,  Zeneng Wang ,  Bruce S. Levison

IPC: G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/493 ,  G01N33/68 ,  G01N33/92 ,  H01J49/00

CPC classification number: G01N33/49 ,  G01N33/493 ,  G01N33/6893 ,  G01N33/92 ,  H01J49/0036 ,  G01N2800/32 ,  G01N2800/323 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  Y10T436/174614

Abstract: Methods of characterizing a test subject's risk of having or developing cardiovascular disease are provided. The methods include using an analytic device to determine levels of choline-related trimethylamine-containing compounds such as trimethylamine N-oxide, choline, or betaine in a biological sample obtained from the subject and comparing the levels of the choline-related trimethylamine-containing compound in the subject's biological sample to a control value. The test subject's risk of having cardiovascular disease is then characterized as higher if the levels of the choline-related trimethylamine-containing compound are higher than the control value. Also provided are methods of identifying a subject at risk of experiencing a complication of atherosclerotic cardiovascular disease, and methods of evaluating the efficacy of a cardiovascular therapeutic agent in a subject with cardiovascular disease using levels of choline-related trimethylamine-containing compounds.

公开(公告)号：US20240230623A9

公开(公告)日：2024-07-11

申请号：US18403577

申请日：2024-01-03

Applicant: Shanghai Kohler Electronics, Ltd.

Inventor： Qintao Sun

IPC: G01N33/493 ,  A61B5/20 ,  A61B10/00

CPC classification number: G01N33/493 ,  A61B5/207 ,  A61B10/007 ,  G16H80/00

Abstract: A method of automatically tracking urine in a toilet includes creating a background image of an interior of a toilet bowl using an image sensor, wherein the background image shows the interior of the toilet bowl. The method also includes acquiring an image of the interior of the toilet bowl using the image sensor, wherein the acquired image shows urine and a collecting and tracking member in the interior of the toilet bowl. The method further includes producing a difference image that shows a difference between the acquired image and the background image, and processing the difference image to identify a location of the urine and the collecting and tracking member, and moving the collecting and tracking member to the identified location of the urine.

公开(公告)号：US12019062B2

公开(公告)日：2024-06-25

申请号：US17742204

申请日：2022-05-11

Applicant: Shanghai Kohler Electronics, Ltd.

Inventor： Zhiyu Qin

IPC: B65D83/08 ,  G01N33/48 ,  G01N33/487 ,  G01N33/493

CPC classification number: G01N33/48757 ,  B65D83/08 ,  G01N33/48 ,  G01N33/493

Abstract: The present invention provides a test paper box and a smart toilet containing same. The test paper box comprises a support and a housing arranged at the outside of the support. The support comprises a base and an elongated cavity arranged at the base for storing test paper. The base is provided with a through hole arranged at a location corresponding to a bottom surface of the elongated cavity. A paper-receiving slot is arranged below the through hole. The paper-receiving slot is fixed to the bottom of the base to receive the bottommost piece of test paper exposed from the elongated cavity, and the paper-receiving slot is provided with a paper outlet. The test paper box can be attached and detached conveniently, delivers test paper smoothly, can be replaced easily, has low costs, and is suitable for smart toilets.

公开(公告)号：US11971356B2

公开(公告)日：2024-04-30

申请号：US18085685

申请日：2022-12-21

Applicant: OUTSENSE DIAGNOSTICS LTD.

Inventor： Ishay Attar ,  Yaara Kapp-Barnea

IPC: G01N21/64 ,  A61B10/00 ,  E03D11/13 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N33/493 ,  G01N33/574

CPC classification number: G01N21/6486 ,  A61B10/0038 ,  A61B10/007 ,  G01J3/10 ,  G01J3/2803 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N21/645 ,  G01N33/493 ,  A61B2010/0006 ,  E03D11/13 ,  G01J2003/104 ,  G01J3/42 ,  G01N2021/6421 ,  G01N33/57419

Abstract: Apparatus and methods are described for use with feces of a subject that are disposed within a toilet bowl. One or more light sensors receive light from the toilet bowl, while the feces are disposed within the toilet bowl. A computer processor detects a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of bile, by analyzing the received light, and detects a presence of bile within the feces, in response to detecting the set of three or more spectral components. The computer processor generates an output in response thereto. Other applications are also described.

公开(公告)号：US11971335B2

公开(公告)日：2024-04-30

申请号：US18198968

申请日：2023-05-18

Applicant: Shanghai Kohler Electronics, Ltd.

Inventor： Zhiyu Qin ,  Qintao Sun

IPC: G01N1/14 ,  E03D9/00 ,  G01F23/263 ,  G01N33/493

CPC classification number: G01N1/14 ,  E03D9/00 ,  G01F23/263 ,  G01N33/493

Abstract: The present disclosure provides a method for collecting liquid comprising: collecting the liquid, by a pump body mechanism, into a cavity of a suction tube assembly; monitoring, by a liquid-level sensing mechanism, an amount of the liquid collected in the cavity; controlling, by the liquid-level sensing mechanism, a start and a stop of collecting the liquid in response to the amount of the liquid collected in the cavity; and cleaning the cavity by delivering, by the pump body mechanism, water into the cavity in response to the stop of collecting the liquid.

公开(公告)号：US20240117407A1

公开(公告)日：2024-04-11

申请号：US18306710

申请日：2023-04-25

Applicant: Concert Pharmaceuticals, Inc.

Inventor： Roger Tung

IPC: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/00 ,  C07D221/28 ,  C07D471/08 ,  G01N33/49 ,  G01N33/493

CPC classification number: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

Abstract: This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

公开(公告)号：US20240103020A1

公开(公告)日：2024-03-28

申请号：US18272428

申请日：2022-01-13

Applicant: QSM Diagnostics, Inc.

Inventor： Edgar D. GOLUCH ,  Nicholas CADIROV

IPC: G01N33/68 ,  G01N27/327 ,  G01N33/487 ,  G01N33/49 ,  G01N33/493

CPC classification number: G01N33/6893 ,  G01N27/3277 ,  G01N33/48714 ,  G01N33/492 ,  G01N33/493 ,  G01N2800/348

Abstract: The present disclosure relates to, inter alia, materials, and methods for detection of infection. More particularly materials, and methods for detecting an infection in a subject's urine or wound exudate are described, e.g. by electrochemically measuring a target molecule and/or a metabolic activity associated with infection using an electrochemical sensor array.

公开(公告)号：US20240102901A1

公开(公告)日：2024-03-28

申请号：US18373110

申请日：2023-09-26

Applicant: SALUS DISCOVERY, LLC

Inventor： Jay Warrick ,  Cody Carrell ,  Brianna Mullins ,  David Beebe ,  Ryan Shogren ,  Patrick McMinn ,  Mitch Geiger ,  Madalyn Gill ,  Jeffrey Robert Staszak ,  Visnu Devi Fraenkel ,  Antonio Gatta ,  Eric S. Mackey ,  McKayla Rae Barber ,  Randi Marie Degg ,  Madeline Sides ,  Douglas Paul Barnes ,  Franklin Cheng Zhong ,  Mindy Phung

IPC: G01N1/40 ,  G01N33/493

CPC classification number: G01N1/4005 ,  G01N33/493 ,  G01N2001/4088

Abstract: Provided herein are devices and methods for isolation and detection of an analyte from a sample. In some embodiments, provided herein are devices and methods of use thereof for vertical flow-based isolation and detection of analytes in a liquid sample, such as a urine sample.