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公开(公告)号：US08246986B2
公开(公告)日：2012-08-21
申请号：US10950003
申请日：2004-09-23
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： Aqueous drug coatings including at least one insoluble drug, wherein the insoluble drug accounts for about 85 wt % to about 97 wt % of the drug coatings are described. Such drug coatings may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs.
摘要翻译： 描述了包含至少一种不溶性药物的水性药物涂层，其中不溶性药物占药物涂层的约85重量％至约97重量％。 这样的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。
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2.发明授权公开(公告)号：US08226979B2
公开(公告)日：2012-07-24
申请号：US13084462
申请日：2011-04-11
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译： 本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。 根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。 本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。
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3.发明申请公开(公告)号：US20110318392A1
公开(公告)日：2011-12-29
申请号：US13084462
申请日：2011-04-11
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/00 , A61P25/04 , A61P29/00 , A61K31/167 , A61K31/485
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译： 本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。 根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。 本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。
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4.发明申请DRUG COATING PROVIDING HIGH DRUG LOADING AND METHODS FOR PROVIDING THE SAME 审中-公开提供高剂量药物的药物涂料及其提供方法公开(公告)号：US20120165361A1
公开(公告)日：2012-06-28
申请号：US13412840
申请日：2012-03-06
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo M. Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K31/485 , A61P25/04 , A61P29/00 , A61K31/167 , A61K47/38
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译： 本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。 根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。 本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。
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5.发明申请公开(公告)号：US20050112195A1
公开(公告)日：2005-05-26
申请号：US10950003
申请日：2004-09-23
申请人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo Wong , Ryan Bronz , Tracy Fink , David Edgren
发明人： Evangeline Cruz , Gregory Ruhlmann , Brenda Pollock , Sherry Li , Carmelita Garcia , Alfredo Wong , Ryan Bronz , Tracy Fink , David Edgren
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48 , A61K9/50 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/485 , A61K31/16
CPC分类号： A61K31/165 , A61K9/0004 , A61K9/1676 , A61K9/2086 , A61K9/209 , A61K9/2886 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/485 , A61K2300/00
摘要： The present invention is directed to aqueous drug coatings that include at least one insoluble drug, wherein the drug accounts for about 85 wt % to about 97 wt % of the drug coatings. A drug coating according to the present invention may include only one insoluble drug, two or more insoluble drugs, or one or more insoluble drugs in combination with one or more soluble drugs. The present invention also includes drug coating formulations suitable for providing drug coatings according to the present invention and dosage forms that include a drug coating according to the present invention.
摘要翻译： 本发明涉及包含至少一种不溶性药物的水性药物包衣，其中药物占药物包衣的约85重量％至约97重量％。 根据本发明的药物涂层可以仅包含一种不溶性药物，两种或更多种不溶性药物，或一种或多种不溶性药物与一种或多种可溶性药物的组合。 本发明还包括适用于提供根据本发明的药物包衣的药物包衣制剂和包括根据本发明的药物包衣的剂型。
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公开(公告)号：US20050089570A1
公开(公告)日：2005-04-28
申请号：US10949180
申请日：2004-09-24
申请人： Evangeline Cruz , Sherry Li , Atul Ayer , Brenda Pollock , Gregory Ruhlmann , Carmelita Garcia , Alfredo Wong , Lawrence Hamel
发明人： Evangeline Cruz , Sherry Li , Atul Ayer , Brenda Pollock , Gregory Ruhlmann , Carmelita Garcia , Alfredo Wong , Lawrence Hamel
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/36 , A61K9/48 , A61K9/50 , A61K31/00 , A61K31/165 , A61K31/485
CPC分类号： A61K9/0004 , A61K9/2086 , A61K9/209 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/165 , A61K31/485 , A61K2300/00
摘要： A sustained release dosage form is provided comprising a pharmaceutically active agent and pharmaceutically acceptable salts thereof and adapted to release as an erodible solid over a prolonged period of time, wherein the dosage form provides burst release of the pharmaceutically active agent without the use of an immediate release drug coating. The dosage form is able to deliver high doses of poorly soluble or slowly dissolving active agents at a controlled rate. Methods of using the dosage forms to treat disease or conditions in human patients are also disclosed.
摘要翻译： 提供持续释放剂型，其包含药物活性剂及其药学上可接受的盐，并适于在较长时间内作为可侵蚀固体释放，其中所述剂型提供药物活性剂的爆发释放，而不使用立即 释放药物涂层。 该剂型能够以受控的速率递送高剂量的难溶性或缓慢溶解的活性剂。 还公开了使用剂型治疗人类患者疾病或病症的方法。
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