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    Novel drug compositions and dosage forms
    7.
    发明申请
    Novel drug compositions and dosage forms 审中-公开
    新型药物组合物和剂型

    公开(公告)号：US20050175690A1

    公开(公告)日：2005-08-11

    申请号：US11024330

    申请日：2004-12-28

    申请人： David Edgren ,  Frank Jao ,  Rhea Kimbel ,  Shaoling Li ,  Noymi Yam ,  Sylvia Seroff ,  Padmaja Shivanand

    发明人： David Edgren ,  Frank Jao ,  Rhea Kimbel ,  Shaoling Li ,  Noymi Yam ,  Sylvia Seroff ,  Padmaja Shivanand

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/24 ,  A61K31/35

    CPC分类号： A61K9/209 ,  A61K9/0004

    摘要： The present invention is directed to novel drug compositions and dosage forms comprising said drug compositions. The drug compositions of the present invention comprise a pharmaceutical agent and a solubilizing agent. The drug compositions of the present invention are particularly advantageous for use with low solubility and/or low dissolution rate pharmaceutical agents. The present invention is further directed to methods for manufacturing of said drug compositions and dosage forms. The present invention is further directed to methods of treatment comprising administration of said drug compositions and dosage forms.

    摘要翻译： 本发明涉及包含所述药物组合物的新型药物组合物和剂型。 本发明的药物组合物包含药剂和增溶剂。 本发明的药物组合物特别适用于低溶解度和/或低溶解速率的药剂。 本发明还涉及制备所述药物组合物和剂型的方法。 本发明进一步涉及包括施用所述药物组合物和剂型的治疗方法。

    Dosage Form for Time-Varying Patterns of Drug Delivery
    10.
    发明申请
    Dosage Form for Time-Varying Patterns of Drug Delivery 审中-公开
    药物递送时间变化模式的剂型

    公开(公告)号：US20070207204A1

    公开(公告)日：2007-09-06

    申请号：US11744999

    申请日：2007-05-07

    申请人： David Edgren ,  Patrick Wong ,  Shu Li

    发明人： David Edgren ,  Patrick Wong ,  Shu Li

    IPC分类号： A61K9/66

    CPC分类号： A61K9/0004 ,  A61K31/277

    摘要： The present invention provides a multi-release oral drug delivery system that initiates drug release following an initial drug-free release interval, after administration to a subject, and a second drug-free release period before release of another dose of drug. The system has (1) inner compartments enclosed within a semipermeable membrane, and (2) a drug coating on the exterior of the semipermeable membrane surrounded by a microporous membrane, which microporous membrane is permeable to fluid and drug. The drug coating is released after the initial drug-free release interval. An inner compartment drug is released after a second drug-free release interval provided by a drug-free inner compartment.

    摘要翻译： 本发明提供一种多次释放的口服药物递送系统，其在给予受试者之后，在初始无药物释放间隔之后启动药物释放，以及释放另一剂量药物之前的第二无药物释放期。 该系统具有（1）封闭在半透膜内的内隔室，（2）由微孔膜包围的半透膜外部的药物涂层，该微孔膜可渗透流体和药物。 药物涂层在初始无药物释放间隔后释放。 在由无药物的内隔室提供的第二无药物释放间隔后释放内室药物。