公开(公告)号：US20150038335A1

公开(公告)日：2015-02-05

申请号：US14357475

申请日：2012-11-12

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov Skog ,  Leileata Russo

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6806 ,  C12N15/1003 ,  C12N15/1017 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The present invention is directed to methods of isolating particles, such as nucleic acid-containing particles or microvesicles, from a biological sample and extracting nucleic acids therefrom, wherein the biological sample is cerebrospinal fluid. The present invention further provides methods for aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker associated with a disease or medical condition thereof.

Abstract translation: 本发明涉及从生物样品中分离出颗粒如含核酸颗粒或微泡，并从其中提取核酸的方法，其中生物样品是脑脊液。 本发明还提供了通过检测与疾病或其医学状况相关的生物标志物来帮助诊断，预后，监测和评估受试者中的疾病或其他医学状况的方法。

公开(公告)号：US10174361B2

公开(公告)日：2019-01-08

申请号：US14357475

申请日：2012-11-12

Applicant: Exosome Diagnostics, Inc.

Inventor： Johan Karl Olov Skog ,  Leileata Russo

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6883 ,  C12N15/10 ,  C12Q1/6886

Abstract: The present invention is directed to methods of isolating particles, such as nucleic acid-containing particles or microvesicles, from a biological sample and extracting nucleic acids therefrom, wherein the biological sample is cerebrospinal fluid. The present invention further provides methods for aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker associated with a disease or medical condition thereof.