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公开(公告)号:US20190249265A1
公开(公告)日:2019-08-15
申请号:US16056016
申请日:2018-08-06
发明人: Li Quan Koh , You Bin Lin , Weishi Zhang
IPC分类号: C12Q1/70 , C12Q1/686 , C12Q1/6806 , C12Q1/6853
CPC分类号: C12Q1/705 , C12Q1/6806 , C12Q1/6853 , C12Q1/686 , C12Q2600/112 , C12Q2600/16 , C12Q2600/166
摘要: A kit for simultaneously detecting HSV1 and HSV2 includes a forward primer and a reverse primer specific to HSV1, and a forward primer and a reverse primer specific to HSV2. The forward primer specific to HSV1 has a sequence of SEQ ID NO: 1 or SEQ ID NO: 4, and the reverse primer specific to HSV1 has a sequence of SEQ ID NO: 2 or SEQ ID NO: 7. The forward primer specific to HSV2 has a sequence of SEQ ID NO: 6, and the reverse primer specific to HSV2 has a sequence of SEQ ID NO: 7.
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公开(公告)号:US20190249249A1
公开(公告)日:2019-08-15
申请号:US15773452
申请日:2016-11-09
申请人: LIFECODEXX AG
发明人: Steffi Werler , Wera Hofmann , Matthias Sachse
IPC分类号: C12Q1/6883 , C12Q1/686 , C12Q1/6806
CPC分类号: C12Q1/6883 , C12Q1/6806 , C12Q1/6851 , C12Q1/686 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2523/125 , C12Q2537/143 , C12Q2545/107
摘要: The present invention relates to methods for detecting a chromosomal aneuploidy in a foetus carried by a pregnant female. Such methods are based on one or more of particular configurations and/or detections and/or analyses of two or more regions of DNA, including those that show differential methylation between DNA that originates from cells of a foetus (and/or the placenta of a foetus) and DNA of maternal origin. Such methods utilise a sample taken from said pregnant female, which sample comprises DNA that originates from cells of a foetus and/or the placenta of a foetus in admixture with differently methylated DNA of maternal origin. Such methods have diagnostic, prognostic and/or predictive utility; in particular for the detection/diagnosis of chromosomal aneuploidy, such as a trisomy, in a foetus, and/or for detecting an increased risk of a pregnant female suffering from or developing a pregnancy-associated medical condition. The present invention also relates to compositions, kits, computer program products and other aspects that may be used in, useful for or related to the practice of such methods.
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公开(公告)号:US20190249247A1
公开(公告)日:2019-08-15
申请号:US16397832
申请日:2019-04-29
申请人: 10X Genomics, Inc.
发明人: Sydney Brenner , Gi Mikawa , Robert Osborne , Andrew Slatter
IPC分类号: C12Q1/6874 , C12Q1/6855 , C12Q1/6806 , C12Q1/686 , C12N15/10
CPC分类号: C12Q1/6874 , C12N15/1065 , C12Q1/6806 , C12Q1/6855 , C12Q1/686 , C12Q2563/179 , C12Q2537/143 , C12Q2535/122 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143
摘要: Aspects of the present invention include analyzing nucleic acids from single cells using methods that include using tagged polynucleotides containing multiplex identifier sequences.
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公开(公告)号:US20190249245A1
公开(公告)日:2019-08-15
申请号:US16262777
申请日:2019-01-30
IPC分类号: C12Q1/6874 , C12Q1/6806 , C12Q1/6837 , C12Q1/6876 , C12Q1/6848 , C40B30/04
CPC分类号: C12Q1/6874 , C12N15/1048 , C12N15/115 , C12N2310/16 , C12N2330/31 , C12Q1/6806 , C12Q1/6837 , C12Q1/6848 , C12Q1/6876 , C40B30/04
摘要: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as lipoarabinomannan (LAM).
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公开(公告)号:US20190241978A1
公开(公告)日:2019-08-08
申请号:US16389596
申请日:2019-04-19
申请人: Inivata Ltd.
发明人: Samuel Woodhouse , Stefanie Lensing , Tim Forshew , Vincent Plagnol , Matthew Edward Smith , Karen Howarth , Michael Epstein
IPC分类号: C12Q1/6886 , C12Q1/6853
CPC分类号: C12Q1/6886 , C12Q1/6806 , C12Q1/6853 , C12Q1/686 , C12Q2600/106 , C12Q2600/16 , G16B20/00 , G16B30/00 , C12Q2525/155 , C12Q2525/161 , C12Q2531/113 , C12Q2535/122 , C12Q2537/159
摘要: The present disclosure relates to methods for detecting and targeting genomic rearrangements, in particular gene fusion events, by targeting a DNA molecule of interest with a set or pool of primers, wherein the forward primers and reverse primers produce a PCR amplification product when a genomic rearrangement is present. The present disclosure also relates to methods of bioinformatic analysis to determine whether or not the detection of an amplification product from the selective PCR is actually indicative of the presence of a gene fusion. The present disclosure also related to related methods of diagnosis and treatment of diseases and conditions associated with such genomic rearrangements, in particular cancers, such as lung cancer.
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公开(公告)号:US20190241953A1
公开(公告)日:2019-08-08
申请号:US16384013
申请日:2019-04-15
发明人: Toumy Guettouche , Aaron Richardson
IPC分类号: C12Q1/6874 , C12N15/10 , C12Q1/6806
CPC分类号: C12Q1/6874 , C12N15/1065 , C12Q1/6806 , C12Q2521/501 , C12Q2525/119 , C12Q2525/155 , C12Q2525/161 , C12Q2525/179 , C12Q2525/186 , C12Q2525/191 , C12Q2525/307 , C12Q2535/122 , C12Q2563/179
摘要: The invention is a novel method of constructing libraries for single-molecule sequencing and a composition therefor. The method utilizes barcodes that enable detection and sequencing of chimeric target molecules with great sensitivity. The method finds application in detection gene fusions such as the ones characteristic of cancer.
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公开(公告)号:US20190233889A1
公开(公告)日:2019-08-01
申请号:US16313706
申请日:2017-04-03
发明人: Hiroyuki ENOKI , Yoshie TAKEUCHI
IPC分类号: C12Q1/6874 , C12N15/10
CPC分类号: C12Q1/6874 , C12N15/09 , C12N15/10 , C12N15/1093 , C12Q1/6806 , C12Q2600/16 , C40B40/06 , C40B50/06 , C12Q2521/101 , C12Q2525/179 , C12Q2531/113 , C12Q2535/122 , C12Q2527/143
摘要: A DNA library with excellent reproducibility is readily produced. A nucleic acid amplification reaction is conducted in a reaction solution containing genomic DNA and a random primer at a high concentration to obtain a DNA fragment by the nucleic acid amplification reaction using the genomic DNA as a template.
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公开(公告)号:US20190232289A1
公开(公告)日:2019-08-01
申请号:US16336322
申请日:2017-09-22
申请人: ArcherDX, Inc.
发明人: Joshua Stahl , Jason Myers
CPC分类号: B01L3/502738 , B01L3/502761 , B01L3/50825 , B01L7/52 , B01L2200/027 , B01L2200/0668 , B01L2200/16 , B01L2300/02 , B01L2300/021 , B01L2300/041 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/1822 , B01L2400/043 , B01L2400/0644 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C1/30 , B03C2201/18 , B03C2201/26 , C07H21/00 , C12Q1/68 , C12Q1/6806 , C12Q1/686 , C40B30/06 , F04C14/14 , G01N1/34 , G01N21/6428 , G01N30/04 , G01N30/6091 , G01N33/54326 , G01N35/00732 , G01N35/0098 , G01N35/02 , G01N35/026 , G01N2030/8827 , G01N2035/00564 , G01N2035/00752 , G16B25/20 , G16B30/00 , G16B35/00 , G16B35/10 , C12Q2563/143 , C12Q2563/149
摘要: Fluidic systems including cartridges with modular components (cassettes) and/or microfluidic channels for performing chemical and/or biological analyses are provided. The systems described herein include a cartridge comprising, in some embodiments, a frame, one or more cassettes which may be inserted into the frame, and a channel system for transporting fluids. In certain embodiments, the one or more cassettes comprise one or more reservoirs or vessels configured to contain and/or receive a fluid (e.g., a stored reagent, a sample). In some cases, the stored reagent may include one or more lyospheres. The systems and methods described herein may be useful for performing chemical and/or biological reactions including polymerase chain reactions (PCR) such as those performed within a laboratory, clinical (e.g., hospital), or research setting.
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公开(公告)号:US20190221316A1
公开(公告)日:2019-07-18
申请号:US16209683
申请日:2018-12-04
IPC分类号: G16H50/50 , C12Q1/6827 , C12Q1/6825 , G06N3/08 , C12Q1/6886 , C12Q1/6806 , G06F17/15 , G06F17/18 , G16H50/30 , G16H50/20 , G06N20/10 , G06N3/04
CPC分类号: G16H50/50 , C12Q1/6806 , C12Q1/6825 , C12Q1/6827 , C12Q1/6886 , G06F17/15 , G06F17/18 , G06N3/0427 , G06N3/086 , G06N20/10 , G16B5/00 , G16B20/00 , G16B40/00 , G16H10/40 , G16H50/20 , G16H50/30 , G16H50/70
摘要: The invention provides biomarkers and combinations of biomarkers useful in diagnosing non-small cell lung cancer. Measurements of these biomarkers are inputted into a classification system such as Random. Forest to assist in determining the likelihood that an individual has non-small cell lung cancer. Kits comprising agents for detecting the biomarkers and combination of biomarkers, as well as systems that assist in diagnosing non-small cell lung cancer are also provided.
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公开(公告)号:US20190219487A1
公开(公告)日:2019-07-18
申请号:US16222933
申请日:2018-12-17
发明人: Joel COLBURN , Mousumi RATH , Sarah GHANBARI
IPC分类号: G01N1/04 , G01N1/28 , C12Q1/6806
CPC分类号: G01N1/04 , B01L3/50825 , B01L2300/042 , B01L2300/046 , B01L2300/0838 , C12Q1/6806 , G01N1/2813 , G01N1/286 , G01N1/34 , G01N2001/028 , G01N2001/045 , G01N2001/284 , G01N2001/2886 , C12Q2521/327 , C12Q2527/101 , C12Q2527/113 , C12Q2531/113 , C12Q2565/601 , C12Q2535/122
摘要: A carrier for holding a biological sample includes a substrate. The substrate is configured to engage a first sample chamber comprising a first opening characterized by a first opening diameter or a second sample chamber comprising a second opening characterized by a second opening diameter that is greater than the first opening diameter. The substrate includes an upper portion, a lower portion, and an intermediate portion disposed between the upper portion and the lower portion. The lower portion is disposed below the upper portion and comprises a bottom surface configured to receive a biological sample. The intermediate portion is characterized by a first substrate diameter and the lower portion is characterized by a second substrate diameter that is less than the first substrate diameter.
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