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公开(公告)号：US20230066188A1
公开(公告)日：2023-03-02
申请号：US18053373
申请日：2022-11-08
Applicant: FUJIFILM CORPORATION
Inventor： Yuta MURAKAMI , Masaya NAGASE , Yukihisa NOGUCHI
Abstract: Provided are a biomarker identifying method including (1) to (4) and an application thereof. (1) An evaluation value for each of a plurality of biomarkers is derived based on annotation information imparted to each of biomarkers, and a measurement target biomarker is selected based on the evaluation value. (2) The evaluation data of the measurement target biomarker is acquired from the cell A and/or the culture system, before the start of culture of the cell A and/or during the culture. (3) The evaluation data of the discrimination marker of the B cell is acquired from the cell A and/or the culture system, at the final stage of the culture of the cell A and/or after the end of the culture. (4) At least one biomarker indicating characteristics of the cell A is identified from among the measurement target biomarkers, based on the data obtained from (2) and (3).
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公开(公告)号：US20210163874A1
公开(公告)日：2021-06-03
申请号：US17172779
申请日：2021-02-10
Applicant: FUJIFILM Corporation
Inventor： Yukihisa NOGUCHI , Masataka HASEGAWA
Abstract: A program for operating a cell culture support apparatus causes a computer to function as a first acquisition unit, a second acquisition unit, and a first derivation unit. The first acquisition unit acquires a learned model indicating a relationship between an initial culture process and a production culture process, derived by performing machine learning on the basis of initial record data for learning including a set of culture condition data indicating a record of culture conditions and culture result data indicating a record of culture results in the initial culture process, and production record data for learning, corresponding to the initial record data for learning and including a set of culture condition data indicating a record of culture conditions and culture result data indicating a record of culture results in the production culture process. The second acquisition unit acquires initial record data for analysis including a set of the culture condition data indicating the record of the culture conditions and the culture result data indicating the record of the culture results in the initial culture process, and temporary culture condition data indicating temporary culture conditions in the production culture process. The first derivation unit derives predicted culture result data obtained by predicting the culture result data in the production culture process, from the learned model acquired in the first acquisition unit, and the initial record data for analysis and the temporary culture condition data acquired in the second acquisition unit.
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