公开(公告)号：US20140309225A1

公开(公告)日：2014-10-16

申请号：US14317001

申请日：2014-06-27

Applicant: FUJIFILM Corporation

Inventor： Hideyasu FUJIWARA ,  Shinsuke MIZUMOTO ,  Yohei KUBO ,  Hiyoku NAKATA ,  Shinji HAGIWARA ,  Yasutaka BABA ,  Takashi TAMURA ,  Hidenobu KUNIYOSHI ,  Tomoyuki MASHIKO ,  Mari YAMAMOTO

IPC: C07D413/12 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D413/12 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04

Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Abstract translation: 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 根据本发明，提供由下式（I）表示的烟酰胺衍生物或其盐，其中R 1为下式（II-1），（III-1）或（IV- 1）（其中R3，R4，R5，n和X1具有与说明书中描述的相同的定义），R2是吡啶基，吲唑基，苯基，吡唑并吡啶基，苯并异恶唑基，嘧啶基或喹啉基， 具有至少一个取代基。