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1.发明申请公开(公告)号：US20220214276A1
公开(公告)日：2022-07-07
申请号：US17702794
申请日：2022-03-24
Applicant: FUJIFILM Corporation
Inventor： Masaharu FUJITA , Takashi TAMURA , Toshihiko KASAHARA , Yusuke YAMAMOTO
Abstract: An object of the present invention is to provide a skin sensitization measuring reagent, a method for measuring skin sensitization, and a compound that allow the sensitization of a test substance to be measured using a single reagent. According to the present invention, there is provided a skin sensitization measuring reagent including, as a main measuring agent, an organic compound having at least one thiol group derived from an amino acid and at least one amino group derived from a side chain of an amino acid. The organic compound has an absorption spectrum in an ultraviolet, visible, or near-infrared region and has a molar absorption coefficient of 100 L/mol·cm or more and 500,000 L/mol·cm or less at a maximal absorption wavelength.
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2.发明申请公开(公告)号：US20200040039A1
公开(公告)日：2020-02-06
申请号：US16577517
申请日：2019-09-20
Applicant: FUJIFILM Corporation
Inventor： Masaaki INOUE , Takashi TAMURA , Yuji YOSHIMITSU , Takahiro HOHSAKA , Takayoshi WATANABE
IPC: C07K7/64
Abstract: An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.
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3.发明公开公开(公告)号：US20230258569A1
公开(公告)日：2023-08-17
申请号：US18303575
申请日：2023-04-20
Applicant: FUJIFILM Corporation
Inventor： Takashi TAMURA , Masaharu FUJITA , Yusuke YAMAMOTO , Koji TAKAKU
CPC classification number: G01N21/77 , C07K7/06 , G01N30/06 , G01N2021/7786 , G01N2030/067
Abstract: An object of the present invention is to provide a reagent for measuring skin sensitization that can measure sensitization to a test substance with high sensitivity using a single type of reagent; a compound; and a method for measuring skin sensitization. According to the present invention, provided are a reagent for measuring skin sensitization including, as a main measuring agent, an organic compound having a mercapto group and a hydrazide structure and having an absorption spectrum in an ultraviolet, visible, or near-infrared region; a compound for use in the reagent for measuring skin sensitization; and a method for measuring skin sensitization using the reagent for measuring skin sensitization.
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公开(公告)号：US20140309225A1
公开(公告)日：2014-10-16
申请号：US14317001
申请日：2014-06-27
Applicant: FUJIFILM Corporation
Inventor： Hideyasu FUJIWARA , Shinsuke MIZUMOTO , Yohei KUBO , Hiyoku NAKATA , Shinji HAGIWARA , Yasutaka BABA , Takashi TAMURA , Hidenobu KUNIYOSHI , Tomoyuki MASHIKO , Mari YAMAMOTO
IPC: C07D413/12 , C07D213/82 , C07D401/12 , C07D401/14
CPC classification number: C07D413/12 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.
Abstract translation: 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 根据本发明，提供由下式（I）表示的烟酰胺衍生物或其盐，其中R 1为下式（II-1），（III-1）或（IV- 1）（其中R3，R4，R5，n和X1具有与说明书中描述的相同的定义），R2是吡啶基，吲唑基，苯基，吡唑并吡啶基，苯并异恶唑基，嘧啶基或喹啉基， 具有至少一个取代基。
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