公开(公告)号：US20160168139A1

公开(公告)日：2016-06-16

申请号：US15052252

申请日：2016-02-24

Applicant: FUJIFILM Corporation

Inventor： Yohei KUBO ,  Makoto ANDO ,  Hidehiko TANAKA ,  Shuhei OSAKA ,  Takuya MATSUMOTO ,  Hiyoku NAKATA ,  Daisuke TERADA ,  Tatsuya NITABARU

IPC: C07D413/14 ,  C07D409/14 ,  C07D498/08 ,  C07D491/048 ,  C07D411/14 ,  C07D498/04 ,  C07D405/14 ,  C07D491/052 ,  C07D411/04 ,  C07D409/04 ,  C07D405/04

CPC classification number: C07D413/14 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K31/55 ,  A61K31/553 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D411/04 ,  C07D411/14 ,  C07D417/14 ,  C07D491/048 ,  C07D491/052 ,  C07D491/056 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08

Abstract: There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

Abstract translation: 提供由通式[1A]表示的吗啉衍生物或其盐。 （式中，环A表示通式[I]表示的环; *表示键合位置，Z 2表示CH等，Z1表示CR 6等，R 6表示氢原子等; X 1表示 CHR 7等; R 7表示氢原子等; X 2表示CH 2等; R 1和R 2相同或不同，R 1和R 2各自表示氢原子等; R 3， R 4和R 5彼此相同或不同，R 3，R 4和R 5各自表示氢原子，NR a R b等; R a和R b分别表示氢原子，C 1-8烷基 可以具有取代基的基团等）

公开(公告)号：US20250086799A1

公开(公告)日：2025-03-13

申请号：US18956007

申请日：2024-11-22

Applicant: FUJIFILM CORPORATION

Inventor： Yohei KUBO ,  Manabu MIYAMOTO ,  Masahiro KUBO

IPC: G06T7/00 ,  G06T7/70

Abstract: An information processing apparatus includes a processor. The processor is configured to: acquire multiple first endoscopic examination images from storage archiving the multiple first endoscopic examination images, the multiple endoscopic examination images having been obtained by imaging multiple sites in a first endoscopic examination which is a previous or earlier endoscopic examination; and cause a display apparatus to display at least one first endoscopic examination image satisfying a specific condition from among the multiple first endoscopic examination images as a reference image in a period of carrying out a second endoscopic examination which is a current endoscopic examination.

公开(公告)号：US20140309225A1

公开(公告)日：2014-10-16

申请号：US14317001

申请日：2014-06-27

Applicant: FUJIFILM Corporation

Inventor： Hideyasu FUJIWARA ,  Shinsuke MIZUMOTO ,  Yohei KUBO ,  Hiyoku NAKATA ,  Shinji HAGIWARA ,  Yasutaka BABA ,  Takashi TAMURA ,  Hidenobu KUNIYOSHI ,  Tomoyuki MASHIKO ,  Mari YAMAMOTO

IPC: C07D413/12 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D413/12 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04

Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Abstract translation: 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 根据本发明，提供由下式（I）表示的烟酰胺衍生物或其盐，其中R 1为下式（II-1），（III-1）或（IV- 1）（其中R3，R4，R5，n和X1具有与说明书中描述的相同的定义），R2是吡啶基，吲唑基，苯基，吡唑并吡啶基，苯并异恶唑基，嘧啶基或喹啉基， 具有至少一个取代基。