公开(公告)号：US09051310B2

公开(公告)日：2015-06-09

申请号：US14317001

申请日：2014-06-27

Applicant: FUJIFILM Corporation

Inventor： Hideyasu Fujiwara ,  Shinsuke Mizumoto ,  Yohei Kubo ,  Hiyoku Nakata ,  Shinji Hagiwara ,  Yasutaka Baba ,  Takashi Tamura ,  Hidenobu Kuniyoshi ,  Tomoyuki Mashiko ,  Mari Yamamoto

IPC: C07D213/82 ,  C07D413/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D405/04

CPC classification number: C07D413/12 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04

Abstract: The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein R1 is a substituent represented by the following formula (II-1), (III-1), or (IV-1) (wherein R3, R4, R5, n, and X1 have the same definitions as those described in the specification), and R2 is a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Abstract translation: 本发明的目的是提供具有优异的Syk抑制活性的化合物和药物组合物。 根据本发明，提供由下式（I）表示的烟酰胺衍生物或其盐，其中R 1为下式（II-1），（III-1）或（IV- 1）（其中R3，R4，R5，n和X1具有与说明书中描述的相同的定义），R2是吡啶基，吲唑基，苯基，吡唑并吡啶基，苯并异恶唑基，嘧啶基或喹啉基， 具有至少一个取代基。

公开(公告)号：US11319347B2

公开(公告)日：2022-05-03

申请号：US16577517

申请日：2019-09-20

Applicant: FUJIFILM Corporation

Inventor： Masaaki Inoue ,  Takashi Tamura ,  Yuji Yoshimitsu ,  Takahiro Hohsaka ,  Takayoshi Watanabe

IPC: C07K7/64

Abstract: An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.