公开(公告)号：US20200378962A1

公开(公告)日：2020-12-03

申请号：US16999138

申请日：2020-08-21

Applicant: FUJIFILM Corporation

Inventor： Hiroyuki CHIKU ,  Takeru SHIGEMURA ,  Kousuke WATANABE ,  Yoshinori KANAZAWA ,  Kouitsu SASAKI ,  Kazuhei KANEKO

IPC: G01N33/543 ,  G01N33/547 ,  G01N21/64

Abstract: An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of progesterone in a wide concentration range from a low concentration to a high concentration, in the measurement of progesterone in a biological sample. The present invention provides a progesterone measuring kit including a first particle having a label and modified with a first binding substance, a second particle having no label and modified with a second binding substance, a flow channel, and a substrate, in which the first particle contains a compound represented by Formula (1) and a particle, and an average particle diameter of the first particles is 50 to 250 nm, an average particle diameter of the second particles is 70 to 500 nm, and the average particle diameter of the second particles is larger than the average particle diameter of the first particles. Each symbol in the formula has the meaning described in the present specification.

公开(公告)号：US20210356474A1

公开(公告)日：2021-11-18

申请号：US17390010

申请日：2021-07-30

Applicant: FUJIFILM Corporation

Inventor： Kazuhiro NAKAMURA ,  Ryo OUCHI ,  Takeru SHIGEMURA

IPC: G01N33/68 ,  G01N33/543 ,  G01N21/64

Abstract: An object of the present invention is to provide a reagent kit, a measurement kit, and a measurement method for measuring serum amyloid A, which enable simple and rapid measurement of serum amyloid A by promoting dissociation of the serum amyloid A from HDL and carrying out an antigen-antibody reaction. According to the present invention, provided is a reagent kit for measuring serum amyloid A, including first particles having a label and modified with a first binding substance having a property of specifically binding to serum amyloid A, at least one nonionic surfactant having an HLB value of 17 to 20, which is defined by (inorganicity value/organicity value)×10, and a molecular weight of 1000 or less, and a buffer capable of adjusting a pH of a reaction solution to be in a range of 5.5 to 7.0 or a range of 8.5 to 9.0.

公开(公告)号：US20210356458A1

公开(公告)日：2021-11-18

申请号：US17389675

申请日：2021-07-30

Applicant: FUJIFILM Corporation

Inventor： Kazuhiro NAKAMURA ,  Ryo OUCHI ,  Takeru SHIGEMURA

IPC: G01N33/545 ,  C07K16/18

Abstract: An object of the present invention is to provide a reagent kit, a measurement kit, and a measurement method for immunologically measuring SAA with high accuracy and high sensitivity without using an alcohol designated as a hazardous material on the fire protection law. According to the present invention, provided is a reagent kit for measuring serum amyloid A, including first particles having a label and modified with a first binding substance having a property of specifically binding to serum amyloid A, at least one nonionic surfactant having a molecular weight of 1000 or less, and a buffer adjusting a pH of a reaction solution to be in a range of 5.5 to 7.0 or a range of 8.5 to 9.0.