公开(公告)号：US20210208138A1

公开(公告)日：2021-07-08

申请号：US17205649

申请日：2021-03-18

申请人： FUJIFILM Corporation

发明人： Yoshihiro ABURAYA ,  Naoyuki NISHIKAWA ,  Junichi KATADA ,  Hiroyuki CHIKU ,  Ayumi ERA

IPC分类号： G01N33/543 ,  C01G49/08 ,  G01N33/531 ,  G01N33/553

摘要： An object of the present invention is to provide a composite particle for an immunochromatography which has excellent spreadability, a method for manufacturing the same, and an immunochromatography using the composite particle for an immunochromatography. A composite particle for an immunochromatography of the present invention is a composite particle for an immunochromatography in which magnetic particles having an average particle size of 500 nm or less and gold particles having an average particle size of 500 nm or less are bound via an organic substance.

公开(公告)号：US20180372737A1

公开(公告)日：2018-12-27

申请号：US16115594

申请日：2018-08-29

申请人： FUJIFILM Corporation

发明人： Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Ayumi ERA

IPC分类号： G01N33/543

摘要： An object of the present invention is to provide a kit for quantitatively determining a bile acid, in which it is possible to improve measurement accuracy by sufficiently dissociating the bile acid from a polymer component, and to rapidly carry out the quantitative determination of the bile acid with high accuracy under various environments, and a method for quantitatively determining the bile acid.According to the present invention, a kit for quantitatively determining a bile acid in a biological sample, including a compound represented by General Formula (I) defined in the present specification in a dry state; a fluorescent particle that has a first binding substance capable of binding to the bile acid; and a substrate that has a detection region having a second binding substance capable of binding to any one of the bile acid and the first binding substance, is provided.

公开(公告)号：US20200096445A1

公开(公告)日：2020-03-26

申请号：US16585406

申请日：2019-09-27

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Tomoaki YOSHIOKA ,  Kousuke WATANABE ,  Kazuhiro HAMADA ,  Kouitsu SASAKI

IPC分类号： G01N21/64 ,  G01N33/543 ,  C07F5/02

摘要： An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance; a second particle having no label and modified with a second binding substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

公开(公告)号：US20200025771A1

公开(公告)日：2020-01-23

申请号：US16585758

申请日：2019-09-27

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Kousuke WATANABE ,  Kazuhei KANEKO ,  Kazuhiro HAMADA ,  Kouitsu SASAKI ,  Tomoaki YOSHIOKA ,  Naoyuki HANAKI

IPC分类号： G01N33/58 ,  C07D209/56

摘要： An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of a measurement target substance in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance, the kit including: a first particle having a label and modified with a first binding substance capable of specifically binding to a measurement target substance; a second particle having no label and modified with a second binding substance incapable of specifically binding to the measurement target substance; a flow channel for flowing the first particle and the second particle; and a substrate having a third binding substance capable of specifically binding to the measurement target substance or a substance capable of binding to the first binding substance, in which the first particle having a label is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle. Each symbol in Formula (1) has the meaning described in the present specification.

公开(公告)号：US20200378962A1

公开(公告)日：2020-12-03

申请号：US16999138

申请日：2020-08-21

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Takeru SHIGEMURA ,  Kousuke WATANABE ,  Yoshinori KANAZAWA ,  Kouitsu SASAKI ,  Kazuhei KANEKO

IPC分类号： G01N33/543 ,  G01N33/547 ,  G01N21/64

摘要： An object of the present invention is to provide a kit, a method, and a reagent which prevent the problem of false positive due to nonspecific adsorption, suppress the increase in noise to be generated, and are capable of achieving high-precision measurement of progesterone in a wide concentration range from a low concentration to a high concentration, in the measurement of progesterone in a biological sample. The present invention provides a progesterone measuring kit including a first particle having a label and modified with a first binding substance, a second particle having no label and modified with a second binding substance, a flow channel, and a substrate, in which the first particle contains a compound represented by Formula (1) and a particle, and an average particle diameter of the first particles is 50 to 250 nm, an average particle diameter of the second particles is 70 to 500 nm, and the average particle diameter of the second particles is larger than the average particle diameter of the first particles. Each symbol in the formula has the meaning described in the present specification.

公开(公告)号：US20200025770A1

公开(公告)日：2020-01-23

申请号：US16583870

申请日：2019-09-26

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Tomoaki YOSHIOKA ,  Kousuke WATANABE ,  Kazuhiro HAMADA ,  Kouitsu SASAKI

IPC分类号： G01N33/58 ,  G01N33/543 ,  C07F5/02 ,  C09K11/06

摘要： An object of the present invention is to provide a kit and a method capable of achieving high-precision measurement of a measurement target substance in a biological sample in a wide concentration range from a low concentration to a high concentration by sufficiently avoiding the influence of antibodies such as anti-serum albumin antibody present in blood. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, the kit including: a labeled particle having a first binding substance capable of binding to the measurement target substance and having a first blocking agent; and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance and having a second blocking agent, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle, and the first blocking agent and the second blocking agent are different from each other. Each symbol in Formula (1) has the meaning described in the present specification.

公开(公告)号：US20180372731A1

公开(公告)日：2018-12-27

申请号：US16115595

申请日：2018-08-29

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Noriyuki KASAGI

IPC分类号： G01N33/543 ,  G01N21/64

摘要： An object of the present invention is to provide a kit in which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy, even in a case where the substance to be measured includes a plurality of substances having different structures. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including fluorescent particles that have a first binding substance capable of binding to the substance to be measured; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, in which the substance to be measured includes at least three types of substances having different structures, and the first binding substance includes at least three types of binding substances which are capable of binding to the at least three types of substances having different structures, respectively, is provided.

公开(公告)号：US20180372638A1

公开(公告)日：2018-12-27

申请号：US16115593

申请日：2018-08-29

申请人： FUJIFILM Corporation

发明人： Noriyuki KASAGI ,  Hiroyuki CHIKU

IPC分类号： G01N21/64 ,  G01N33/553 ,  G01N33/531

摘要： An object of the present invention is to provide a kit and a method by which a quantitative determination of a substance to be measured in a biological sample can be carried out with high accuracy while avoiding the influence of an antibody such as an anti-serum albumin antibody present in blood. According to the present invention, a kit for quantitatively determining a substance to be measured in a biological sample, the kit including: a labeled particle that has a first binding substance capable of binding to the substance to be measured, and a first blocking agent; and a substrate that has a detection region having a second binding substance capable of binding to any one of the substance to be measured and the first binding substance, and a second blocking agent, in which the first blocking agent and the second blocking agent are different from each other, is provided.

公开(公告)号：US20200033334A1

公开(公告)日：2020-01-30

申请号：US16585231

申请日：2019-09-27

申请人： FUJIFILM Corporation

发明人： Hiroyuki CHIKU ,  Kousuke WATANABE ,  Kazuhei KANEKO ,  Kazuhiro HAMADA ,  Kouitsu SASAKI ,  Tomoaki YOSHIOKA ,  Naoyuki HANAKI

IPC分类号： G01N33/543 ,  G01N21/76 ,  C07F5/02 ,  C09K11/06

摘要： An object of the present invention is to provide a kit and a method capable of achieving high-precision measurement of a measurement target substance in a biological sample in a wide concentration range from a low concentration to a high concentration. According to the present invention, there is provided a kit for measuring a measurement target substance in a biological sample, the kit including: a labeled particle having a first binding substance capable of binding to the measurement target substance in a biological sample and having a first blocking agent; and a substrate having a second binding substance capable of binding to any one of the measurement target substance or the first binding substance and having a second blocking agent, in which the labeled particle is a luminescent labeled particle containing at least one kind of compound represented by Formula (1) and a particle, and the first blocking agent and the second blocking agent are different from each other. Each symbol in Formula (1) has the meaning described in the present specification.

公开(公告)号：US20160069909A1

公开(公告)日：2016-03-10

申请号：US14840710

申请日：2015-08-31

申请人： FUJIFILM Corporation

发明人： Kazuhiro NAKAMURA ,  Noriyuki KASAGI ,  Hiroyuki CHIKU ,  Kentaro NAKAMURA

IPC分类号： G01N33/74 ,  G01N33/58 ,  G01N33/553

CPC分类号： G01N33/74 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2333/695

摘要： The present invention provides a reagent kit which is used for measuring a test substance in a biological sample and can improve measurement sensitivity of the test substance; measurement kit; and a method of measuring the test substance. Provided is a reagent kit which is used for measuring the above-described test substance in the biological sample and contains first particles which are modified by a first binding substance having specific binding properties with respect to the test substance and have a label, and a compound which has at least one amino group having a positive charge.

摘要翻译： 本发明提供了一种用于测量生物样品中测试物质并可提高测试物质的测量灵敏度的试剂盒; 测量套件; 以及测定被检物质的方法。 提供一种试剂盒，其用于测量生物样品中的上述测试物质，并含有由相对于被检物质具有特异性结合特性的第一结合物修饰并具有标记的第一颗粒和化合物 其具有至少一个具有正电荷的氨基。