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1.发明授权公开(公告)号：US06178968B2
公开(公告)日：2001-01-30
申请号：US09306863
申请日：1999-05-07
IPC分类号： A61M2900
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/12109 , A61B17/12145 , A61B17/12172 , A61M2025/018
摘要： Methods for utilizing a device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to a) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Disclosed are methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译： 用于在内窥镜引导下利用用于阻塞（例如栓塞）解剖通道的侧分支的装置的方法。 该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。 内置的内窥镜可用于a）目视定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。 公开了在血管腔视觉下进行静脉侧支的原位栓塞的方法。 该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。
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2.发明授权Endoscopically-assisted device for endoluminal occlusion of anatomical passageway side branches 失效内窥镜辅助装置用于解剖通道侧枝的腔内闭塞
公开(公告)号：US5947994A
公开(公告)日：1999-09-07
申请号：US910944
申请日：1997-08-08
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B2017/22097 , A61M2025/018
摘要： The device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to A) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Also disclosed are methods for utilizing a device of the forgoing character, including methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译： 用于在内窥镜引导下阻塞（例如，栓塞）解剖通道的侧分支的装置。 该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。 所配置的内窥镜可用于A）可视地定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。 还公开了用于利用前述特征的装置的方法，包括在血管视觉可视化下进行静脉侧枝的原位栓塞的方法。 该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。
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3.发明授权Side branch occlusion catheter device having integrated endoscope for performing endoscopically visualized occlusion of the side branches of an anatomical passageway 失效具有用于进行解剖通道的侧分支的内窥镜可视化闭塞的集成内窥镜的侧分支闭塞导管装置
公开(公告)号：US5707389A
公开(公告)日：1998-01-13
申请号：US486038
申请日：1995-06-07
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/1214 , A61B2017/22097 , A61M2025/018
摘要： The device for blocking (e.g., embolizing) the side branches of an anatomical passageway under endoscopic guidance. The device comprises an elongate catheter body having a side branch blocking apparatus, such as an embolization catheter, disposed therein and further incorporating an endoscope (e.g., an angioscope). The incorporated endoscope is useable to A) visually locate side branches which emanate from the anatomical passageway and b) visually observe the operation of the side branch blocking apparatus. Also disclosed are methods for utilizing a device of the forgoing character, including methods for performing in situ embolization of the side branches of a vein, under angioscopic visualization. The endoscopic component of the device may also be utilized to visually observe the use and/or effect of one or more separate device, such as valvulotome(s) used for cutting venous valves located within the lumen of a vein.
摘要翻译： 用于在内窥镜引导下阻塞（例如，栓塞）解剖通道的侧分支的装置。 该装置包括细长导管体，其具有设置在其中并进一步结合内窥镜（例如，血管造影仪）的侧分支阻塞装置，例如栓塞导管。 所配置的内窥镜可用于A）可视地定位从解剖通道发出的侧分支，以及b）目视观察侧支阻断装置的操作。 还公开了用于利用前述特征的装置的方法，包括在血管视觉可视化下进行静脉侧枝的原位栓塞的方法。 该装置的内窥镜部件也可以用于目视观察一个或多个分离装置（例如用于切割位于静脉内腔内的静脉瓣）的瓣膜切开的使用和/或效果。
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4.发明授权Radioactive medical devices for inhibiting a hyperplastic response of biological tissue 失效用于抑制生物组织增生反应的放射性医疗装置
公开(公告)号：US6042600A
公开(公告)日：2000-03-28
申请号：US236756
申请日：1999-01-25
CPC分类号： A61B17/06166 , A61N5/1001 , A61N2005/1019 , A61N2005/1089
摘要： Generally described, the present invention comprises a medical device for implantation in biological tissue and a method of making the medical device. The medical device comprises an organic compound forming at least a portion of the medical device and a beta radiation emitting element chemically bonded to the organic compound of the medical device. The beta emitter preferably causes the medical device to generate a beta radiation greater than 0.0002 .mu.Ci/cm. The beta radiation emitting element can be tritium preferably incorporated into the organic compound of the medical device by a Wilzbach process. The Wilzbach process involves an entropic exchange of the beta emitting element for elemental hydrogen in a vacuum sealed reaction chamber. On the other hand, the beta radiation emitting element may comprise Carbon 12, or other similar beta emitter, which is incorporated directly into the backbone of the organic compound prior to manufacturing the medical device from the organic compound. In another aspect of the present invention, rather than placing the medical device itself in a reaction chamber for incorporation of a beta emitting element, a mass of organic material may be placed in a reaction chamber. Again, a beta emitting element is preferably incorporated into the organic material via the Wilzbach process.
摘要翻译： 通常描述，本发明包括用于植入生物组织的医疗装置和制造该医疗装置的方法。 医疗装置包括形成医疗装置的至少一部分的有机化合物和化学键合到医疗装置的有机化合物的β辐射发射元件。 β发射体优选地使医疗装置产生大于0.0002μCi/ cm的β辐射。 β辐射发射元件可以是氚，优选通过Wilzbach方法结合到医疗器件的有机化合物中。 Wilzbach工艺涉及在真空密封的反应室中用于元素氢的β发射元件的熵交换。 另一方面，β辐射发射元件可以包括碳12或其它类似的β发射体，其在从有机化合物制造医疗装置之前直接并入有机化合物的主链。 在本发明的另一方面，不是将医疗装置本身放置在用于结合β发射元件的反应室中，可以将大量有机材料放置在反应室中。 再次，优选的是通过Wilzbach工艺将β发射元件并入有机材料中。
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公开(公告)号：US5897573A
公开(公告)日：1999-04-27
申请号：US837710
申请日：1997-04-22
CPC分类号： A61N5/1001 , A61B17/06166 , A61B2090/392 , A61N2005/1019 , A61N2005/1089
摘要： A radioactive suture for inhibiting an intimal hyperplastic response comprises a needle and a suture material having a radioactive beta-emitting element. This radioactive element is preferably chemically bonded to an organic substrate of the suture material. It is preferred that the radioactive suture material generates a beta radiation greater than 0.0002 uCi/cm. A first preferred method for producing the radioactive suture comprises the steps of placing the suture needle and the suture material in a sealed reaction chamber. Once the suture is in the reaction chamber, an ionized beta radiation emitting element, preferably ionized tritium, is introduced into the chamber. While in the chamber, an entropic exchange process begins wherein the beta radiation emitting element is exchanged for hydrogen molecules in the organic suture material. Once the desired level of tritium or other beta radiation emitting element is incorporated in the suture material, the reaction chamber is flushed. The suture is then rinsed, dried, removed from the reaction chamber, and packaged. In another aspect, a radioactive suture may be fabricated from an organic polypropylene material. A beta radiation emitting element, preferably tritium, is incorporated directly into a backbone of the organic polypropylene material. The now radioactive polypropylene material is extruded into a suture thread, which is attached to a suture needle and packaged for shipment and later use. Although not required by the present inventive method, the preferred embodiment of the organic polypropylene material comprises carbon 12.
摘要翻译： 用于抑制内膜增生反应的放射性缝线包括具有放射性β发射元件的针和缝线材料。 该放射性元素优选化学键合到缝合材料的有机基底上。 放射性缝合材料优选产生大于0.0002μCi/ cm的β辐射。 用于生产放射性缝合线的第一优选方法包括以下步骤：将缝合针和缝合材料放置在密封的反应室中。 一旦缝合线在反应室中，电离的β辐射发射元件，优选离子化的氚被引入腔室。 在腔室中，开始熵交换过程，其中β辐射发射元件被交换为有机缝合材料中的氢分子。 一旦将所需水平的氚或其它β辐射发射元件并入缝合材料中，则反应室被冲洗。 然后将缝合线冲洗，干燥，从反应室中取出并包装。 另一方面，放射性缝线可由有机聚丙烯材料制成。 β辐射发射元件，优选氚直接掺入有机聚丙烯材料的主链。 现在的放射性聚丙烯材料被挤出成缝合线，其被连接到缝合针上并被包装用于运输和稍后使用。 虽然本发明方法不是必需的，但有机聚丙烯材料的优选实施方案包括碳12。
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公开(公告)号：US5584842A
公开(公告)日：1996-12-17
申请号：US253929
申请日：1994-06-30
CPC分类号： A61B17/32075 , A61B17/320725 , A61B2017/22097
摘要： A valvulotome for disrupting vein valves in in-situ procedures, and for distrupting the vein valves in vein segments to be used in CABG procedures. The valvulotome includes an elongate blade mounting member and a thin, scythe-shaped cutting blade. The cutting blade is mounted relative to the blade mounting member such that the plane defined by the blade lies on the axis defined by the blade mounting member. The cutting blade has a fixed end, a free end, a cutting edge and a blunt back edge. The fixed end is fixedly attached to a distal portion of the blade mounting member. The sharpened edge faces towards the blade mounting member, which protects the vein from the sharpened edge. The sharpened edge arcs outwards and proximally from the distal portion of the blade mounting member, and terminates in a proximal portion, spaced from the blade mounting member. The blunt back edge is opposite the sharpened edge, facing the vein. The free end is opposite the fixed end and connects the blunt back edge to the proximal portion of the sharpened edge. The free end including a blunt proximal-facing portion that forms a continuation of the blunt back edge.
摘要翻译： 用于在现场手术中破坏静脉瓣的瓣膜切开术，以及用于扰乱CABG手术中使用的静脉节段中的静脉瓣。 瓣膜切开机包括细长的刀片安装构件和薄的Scythe形切割刀片。 切割刀片相对于刀片安装部件安装，使得由刀片限定的平面位于由刀片安装部件限定的轴线上。 切割刀片具有固定端，自由端，切削刃和钝的后缘。 固定端固定地附接到刀片安装构件的远端部分。 锋利的边缘面向刀片安装构件，其保护静脉免受锋利的边缘的影响。 锋利的边缘从叶片安装构件的远侧部分向外和近侧弧形，并且终止于与叶片安装构件间隔开的近端部分。 钝的后缘与锋利的边缘相对，面向静脉。 自由端与固定端相对，并将钝后缘连接到锐化边缘的近端部分。 自由端包括形成钝后缘的延续的钝的近端部分。
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公开(公告)号：US20080243071A1
公开(公告)日：2008-10-02
申请号：US11694536
申请日：2007-03-30
IPC分类号： A61M31/00
CPC分类号： A61F5/0003 , A61F5/0036 , A61F5/0046
摘要： A gastric space filler device for treating obesity in a patient by reducing the stomach volume features at least one inflatable space filler with drag delivery and stimulation features and includes therapeutic devices and anchoring apparatus enabling tracking, visualization and optimized management of inter-balloon connecting sections, drug reservoirs and pumping systems along with related improvements.
摘要翻译： 一种用于通过减少胃体积特征的用于治疗患者肥胖的胃空间填充装置，具有药物递送和刺激特征的至少一个可充气空间填充物，并且包括能够跟踪，可视化和优化管理球囊间连接部分的治疗装置和锚定装置， 药物储库和抽水系统以及相关改进。
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公开(公告)号：US5250025A
公开(公告)日：1993-10-05
申请号：US819452
申请日：1992-01-10
CPC分类号： A61M25/1011 , A61B17/221 , A61B17/22022 , A61B18/26
摘要： A percutaneous access catheter is employed for examining and treating internal body cavities and organs via an access tract. For example, the catheter can be employed for examining and treating the gallbladder via a transhepatic tract. The examination may employ endoscopic, fluoroscopic, ultrasonic, or other techniques; the treatment may employ surgical, chemical, or physical modalities. The catheter includes two inflation elements. These inflation elements control hemorrhaging and leakage of fluids from the internal body cavity or organ and reduce migration of the catheter within the internal body cavity or organ during the examination and/or treatment. The first inflation element is a toroidal elastic balloon located at the distal end of the device which serves to restrict the accidental or unintended removal of the distal end from the internal body cavity or organ. The second inflation device is an inflatable nondistensible sleeve which serves to anchor the device to the access tract during the medical procedure. The two inflation elements can act cooperatively so as to anchor the internal body cavity or organ to the access tract and so as to reduce the migration of the distal end of the device within the internal body cavity or organ. The inflation of the inflatable nondistensible sleeve can also serve to control hemorrhaging from the access tract by the application of tamponage without causing unwanted dilation thereof.
摘要翻译： 采用经皮通路导管，通过入路检查和处理内部体腔和器官。 例如，导管可用于通过经肝脏管检查和治疗胆囊。 检查可采用内窥镜，荧光镜，超声波或其他技术; 治疗可以采用手术，化学或物理方式。 导管包括两个充气元件。 这些通气元件控制流体从内部体腔或器官的出血和泄漏，并且在检查和/或治疗期间减少导管在内部体腔或器官内的迁移。 第一膨胀元件是位于装置的远端处的环形弹性球囊，其用于限制远端从内部体腔或器官的意外或非预期的移除。 第二充气装置是可膨胀的不可靠的套筒，其用于在医疗过程期间将装置锚定到进入管道。 两个充气元件可以协同地起作用以将内部体腔或器官锚固到进入管道上，并且减小装置在内部体腔或器官内的远端的迁移。 可膨胀不可渗透的套管的膨胀也可以用于通过施用棉塞来控制从进入管道出血而不引起不希望的扩张。
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公开(公告)号：US08226602B2
公开(公告)日：2012-07-24
申请号：US11694536
申请日：2007-03-30
CPC分类号： A61F5/0003 , A61F5/0036 , A61F5/0046
摘要： A gastric space filler device for treating obesity in a patient by reducing the stomach volume features at least one inflatable space filler with drag delivery and stimulation features and includes therapeutic devices and anchoring apparatus enabling tracking, visualization and optimized management of inter-balloon connecting sections, drug reservoirs and pumping systems along with related improvements.
摘要翻译： 一种用于通过减少胃体积特征的用于治疗患者肥胖的胃空间填充装置，具有药物递送和刺激特征的至少一个可充气空间填充物，并且包括能够跟踪，可视化和优化管理球囊间连接部分的治疗装置和锚定装置， 药物储库和抽水系统以及相关改进。
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公开(公告)号：US20070149994A1
公开(公告)日：2007-06-28
申请号：US11452670
申请日：2006-06-14
IPC分类号： A61M29/00
CPC分类号： A61F5/0076 , A61F5/003 , A61F5/0033 , A61F5/0036 , A61F5/004
摘要： A gastric space filler device for treating obesity in a patient by reducing the stomach volume comprising at least one inflatable space filler and a pressure sensor secured to the space filler, wherein the pressure sensor yields a noticeable signal for causing removal of the space filler.
摘要翻译： 一种胃空间填充装置，用于通过减少包括至少一个可充气空间填充物和固定在空间填充物上的压力传感器的胃体积来治疗患者的肥胖，其中所述压力传感器产生用于引起空间填充物移除的明显信号。
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