公开(公告)号：US20230184747A1

公开(公告)日：2023-06-15

申请号：US18104825

申请日：2023-02-02

Applicant: GENENTECH, INC.

Inventor： Shan Chung ,  Sivan Cohen

IPC: G01N33/50 ,  C12N5/0783 ,  G01N33/68

CPC classification number: G01N33/5047 ,  C12N5/0636 ,  G01N33/6854

Abstract: The presently disclosed subject matter provides methods for determining the propensity of a composition, e.g., a composition comprising an antibody or a fragment thereof, to elicit production of anti-drug antibodies (ADAs) and kits for performing such methods.

公开(公告)号：US20230160907A1

公开(公告)日：2023-05-25

申请号：US18153259

申请日：2023-01-11

Applicant: GENENTECH, INC.

Inventor： Lynn Anne Kamen ,  Rachel Ann Melendez ,  Shan Chung

IPC: G01N33/68 ,  G01N33/50

CPC classification number: G01N33/6854 ,  G01N33/5047

Abstract: The presently disclosed subject matter provides methods for determining the propensity of a polypeptide or a fragment thereof, e.g., an antibody or a fragment thereof, to elicit production of anti-drug antibodies (ADAs) and kits for performing such methods.

公开(公告)号：US20220033520A1

公开(公告)日：2022-02-03

申请号：US17343543

申请日：2021-06-09

Applicant: Genentech, Inc.

Inventor： Gregory A. Lazar ,  James Ernst ,  Jasvinder Atwal ,  Shraddha Shirish Sadekar ,  Yanli Yang ,  Shan Chung

IPC: C07K16/40 ,  A61P25/28 ,  C07K16/18

Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.