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公开(公告)号：US09879094B2
公开(公告)日：2018-01-30
申请号：US15234649
申请日：2016-08-11
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07H21/04 , C07K16/18 , C12P21/08 , C07K16/40 , A61K39/395 , G01N33/573 , C12P21/00 , A61K47/68 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
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公开(公告)号：US20220033520A1
公开(公告)日：2022-02-03
申请号：US17343543
申请日：2021-06-09
Applicant: Genentech, Inc.
Inventor： Gregory A. Lazar , James Ernst , Jasvinder Atwal , Shraddha Shirish Sadekar , Yanli Yang , Shan Chung
Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.
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公开(公告)号：US10882920B2
公开(公告)日：2021-01-05
申请号：US15525791
申请日：2015-11-18
Applicant: Genentech, Inc. , Adimab LLC
Inventor： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus
IPC: C07K16/40 , A61K47/68 , A61K39/00 , G01N33/573
Abstract: The invention provides antagonistic antibodies to BACE1 and methods of using the same for the treatment of neurological disease and disorders.
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公开(公告)号：US20180057604A1
公开(公告)日：2018-03-01
申请号：US15525821
申请日：2015-11-18
Applicant: Genentech, Inc. , Adimab LLC
Inventor： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan WU , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
CPC classification number: C07K16/40 , A61K2039/505 , C07K16/22 , C07K16/2881 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12Y304/23046 , G01N33/6896 , G01N2333/70582 , G01N2333/96472 , G01N2800/28 , G01N2800/52
Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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公开(公告)号：US11008403B2
公开(公告)日：2021-05-18
申请号：US15525821
申请日：2015-11-18
Applicant: Genentech, Inc. , Adimab LLC
Inventor： Yichin Liu , Jasvinder Atwal , Cecilia Pui Chi Chiu , Ryan J. Watts , Yan Wu , Eric Krauland , Michael Feldhaus , Yin Zhang , Joy Yu Zuchero , Jessica Couch , Mark S Dennis , James A Ernst , Gregory A Lazar
Abstract: The present invention relates to bispecific antibodies that bind to transferrin receptor and BACE1 and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US10808036B2
公开(公告)日：2020-10-20
申请号：US15614149
申请日：2017-06-05
Applicant: Genentech, Inc.
Inventor： Yin Zhang , Joy Yu Zuchero , Jasvinder Atwal , Jessica Couch , Mark S. Dennis , James A. Ernst , Ryan J. Watts , Gregory A. Lazar
Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
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公开(公告)号：US20180002433A1
公开(公告)日：2018-01-04
申请号：US15614149
申请日：2017-06-05
Applicant: Genentech, Inc.
Inventor： Yin Zhang , Joy Yu Zuchero , Jasvinder Atwal , Jessica Couch , Mark S. Dennis , James A. Ernst , Ryan J. Watts , Gregory A. Lazar
Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
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公开(公告)号：US09708406B2
公开(公告)日：2017-07-18
申请号：US14283038
申请日：2014-05-20
Applicant: Genentech, Inc.
Inventor： Yin Zhang , Joy Yu Zuchero , Jasvinder Atwal , Jessica Couch , Mark S. Dennis , James A. Ernst , Ryan J. Watts , Gregory A. Lazar
CPC classification number: C07K16/2881 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
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公开(公告)号：US09453079B2
公开(公告)日：2016-09-27
申请号：US14292461
申请日：2014-05-30
Applicant: Genentech, Inc.
Inventor： Jasvinder Atwal , Yongmei Chen , Cecilia Pui Chi Chiu , Robert A. Lazarus , Weiru Wang , Ryan J. Watts , Yan Wu , Yingnan Zhang
IPC: C07K16/18 , A61K39/395 , C07K16/40 , A61K47/48 , G01N33/573 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K47/6871 , A61K2039/505 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12P21/005 , G01N33/573
Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
Abstract translation: 本发明提供了针对特定神经蛋白的抗体及其使用方法。
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公开(公告)号：US11098129B2
公开(公告)日：2021-08-24
申请号：US16670104
申请日：2019-10-31
Applicant: Genentech, Inc.
Inventor： Yin Zhang , Joy Yu Zuchero , Jasvinder Atwal , Jessica Couch , Mark S Dennis , James A Ernst , Ryan J Watts , Gregory A Lazar
IPC: C07K16/28 , C07K16/40 , A61K39/395 , A61K39/00
Abstract: The present invention relates to anti-transferrin receptor antibodies and methods of their use.
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