公开(公告)号：US11046776B2

公开(公告)日：2021-06-29

申请号：US15669861

申请日：2017-08-04

Applicant: Genentech, Inc.

Inventor： Greg Lazar ,  Yanli Yang ,  Erin H. Christensen ,  Julie Hang ,  Jeong Kim ,  Seth Harris

IPC: A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  A61K39/00

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

公开(公告)号：US20220033520A1

公开(公告)日：2022-02-03

申请号：US17343543

申请日：2021-06-09

Applicant: Genentech, Inc.

Inventor： Gregory A. Lazar ,  James Ernst ,  Jasvinder Atwal ,  Shraddha Shirish Sadekar ,  Yanli Yang ,  Shan Chung

IPC: C07K16/40 ,  A61P25/28 ,  C07K16/18

Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.