公开(公告)号：US10173978B2

公开(公告)日：2019-01-08

申请号：US15749383

申请日：2016-08-02

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Shujie Hou ,  Partha Banerjee ,  Karishma Amin

IPC: A61K31/403 ,  C07D209/88 ,  A61P35/00 ,  A61K45/06

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

公开(公告)号：US20190077755A1

公开(公告)日：2019-03-14

申请号：US16182720

申请日：2018-11-07

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Shujie Hou ,  Partha Banerjee ,  Karishma Amin

IPC: C07D209/88 ,  A61K45/06 ,  A61K31/403 ,  A61P35/00

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

公开(公告)号：US20200247751A1

公开(公告)日：2020-08-06

申请号：US16661510

申请日：2019-10-23

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Shujie Hou ,  Partha Banerjee ,  Karishma Amin

IPC: C07D209/88 ,  A61K45/06 ,  A61P35/00 ,  A61K31/403

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

公开(公告)号：US11104646B2

公开(公告)日：2021-08-31

申请号：US16661510

申请日：2019-10-23

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Shujie Hou ,  Partha Banerjee ,  Karishma Amin

IPC: C07D209/88 ,  A61K45/06 ,  A61P35/00 ,  A61K31/403

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.

公开(公告)号：US20180215712A1

公开(公告)日：2018-08-02

申请号：US15749383

申请日：2016-08-02

Applicant: GEORGETOWN UNIVERSITY

Inventor： Milton L. Brown ,  Shujie Hou ,  Partha Banerjee ,  Karishma Amin

IPC: C07D209/88 ,  A61K31/403 ,  A61P35/00 ,  A61K45/06

CPC classification number: C07D209/88 ,  A61K31/403 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.