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公开(公告)号:US20220409895A1
公开(公告)日:2022-12-29
申请号:US17872432
申请日:2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US20230271010A1
公开(公告)日:2023-08-31
申请号:US18140387
申请日:2023-04-27
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/36139 , A61N1/36178 , A61N1/36135 , A61N1/3614 , A61N1/36171 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US11446496B2
公开(公告)日:2022-09-20
申请号:US16955393
申请日:2018-12-20
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US12161869B2
公开(公告)日:2024-12-10
申请号:US18140387
申请日:2023-04-27
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US11633601B2
公开(公告)日:2023-04-25
申请号:US16955282
申请日:2018-12-20
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Robert Coatney , Cindy Cleypool
Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.
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公开(公告)号:US20250128064A1
公开(公告)日:2025-04-24
申请号:US18930609
申请日:2024-10-29
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro-and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号:US11738196B2
公开(公告)日:2023-08-29
申请号:US17872432
申请日:2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor: Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/3614 , A61N1/36135 , A61N1/36139 , A61N1/36171 , A61N1/36178 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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