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公开(公告)号：US20230271010A1
公开(公告)日：2023-08-31
申请号：US18140387
申请日：2023-04-27
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
CPC classification number: A61N1/3606 , A61N1/0556 , A61N1/36139 , A61N1/36178 , A61N1/36135 , A61N1/3614 , A61N1/36171 , A61N2001/083
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号：US11672972B2
公开(公告)日：2023-06-13
申请号：US15733276
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor： Rizwan Bashirullah , Gerald Edwin Hunsberger , Matteo Donega , Daniel Chew , David Holder , Kirill Aristovich
CPC classification number: A61N1/0556 , A61N1/36053 , A61N1/36182
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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公开(公告)号：US11464978B2
公开(公告)日：2022-10-11
申请号：US16955345
申请日：2018-12-20
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US20220249840A1
公开(公告)日：2022-08-11
申请号：US17619215
申请日：2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor： Isha Gupta , Matteo Donega
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging, shock, acute respiratory distress syndrome (ARDS), severe respiratory distress syndrome (SARS), and coronavirus disease 19 (COVID-19).
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公开(公告)号：US12296171B2
公开(公告)日：2025-05-13
申请号：US17872319
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
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Patent Agency Ranking
公开(公告)号：US12083340B2
公开(公告)日：2024-09-10
申请号：US18141045
申请日：2023-04-28
Applicant: Galvani Bioelectronics Limited
Inventor： Daniel John Chew , Matteo Donega , Isha Gupta
CPC classification number: A61N1/36071 , A61N1/0553 , A61N1/0556 , A61N1/205 , A61N1/36135 , A61N1/3616 , A61N1/36171
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen provides a useful way to treat acute medical conditions. The disclosed systems and methods stimulate the neural activity of a nerve supplying a spleen, wherein the nerve is associated with a neurovascular bundle, such that the electrical signal produces an improvement in a physiological parameter indicative of treatment of an acute medical condition.
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公开(公告)号：US11724102B2
公开(公告)日：2023-08-15
申请号：US17872829
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Matteo Donega , Daniel John Chew , Margarita J. Vervoordeldonk , Isha Gupta
CPC classification number: A61N1/0556 , A61N1/0553 , A61N1/36053 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36135 , A61N1/36171 , A61N1/3787
Abstract: Electrical stimulation of neural activity in the neural innervation of the spleen that is associated with neurovascular bundles provides a useful way to treat acute medical conditions, such as trauma, hemorrhaging and shock.
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公开(公告)号：US20220409895A1
公开(公告)日：2022-12-29
申请号：US17872432
申请日：2022-07-25
Applicant: Galvani Bioelectronics Limited
Inventor： Margarita J. Vervoordeldonk , Eric Irwin , Daniel John Chew , Matteo Donega , Cindy Cleypool , Isha Gupta
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is adjacent to the splenic artery at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.
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公开(公告)号：US20220409887A1
公开(公告)日：2022-12-29
申请号：US17619205
申请日：2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor： Isha Gupta , Matteo Donega
Abstract: Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can re-programme immune cells in the spleen, modulate pro- and anti-inflammatory molecules levels, and induce disease-resolution pathways system-ically thereby reducing inflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.
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公开(公告)号：US20220241590A1
公开(公告)日：2022-08-04
申请号：US17619223
申请日：2020-06-17
Applicant: Galvani Bioelectronics Limited
Inventor： Isha Gupta , Matteo Donega
Abstract: Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.
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