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公开(公告)号：US20200316372A1
公开(公告)日：2020-10-08
申请号：US15733276
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor： Rizwan BASHIRULLAH , Gerald Edwin HUNSBERGER , Matteo DONEGA , Daniel CHEW , David Holder , Kirill ARISTOVICH
Abstract: A nerve interface device including at least one cuff portion having an assembled position in which the cuff portion forms at least part of a passageway for receiving a nerve along a longitudinal axis passing through the passageway; and first and second rings of electrodes mounted on the at least one cuff portion, each ring of electrodes including a plurality of electrodes. Each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The plurality of pairs of electrodes includes at least a first pair of electrodes, the first pair of electrodes mounted on the at least one cuff portion. The at least one cuff portion includes an asymmetric configuration about a central axis perpendicular to the longitudinal cuff axis.
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公开(公告)号：US20210093867A1
公开(公告)日：2021-04-01
申请号：US15733274
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited , UCL Business PLC
Inventor： Matteo DONEGA , Daniel CHEW , David Holder , Kirill ARISTOVICH , Rizwan BASHIRULLAH
Abstract: A nerve stimulation system is disclosed including a nerve interface device having a cuff that receives a nerve of a user; and first and second rings of electrodes mounted on the cuff, each ring of electrodes including a plurality of electrodes and wherein each electrode in the first ring has a corresponding longitudinally-aligned electrode in the second ring so as to form a plurality of pairs of electrodes spaced apart from each other along the longitudinal axis. The system includes a stimulation device in communication with the pairs of electrodes to generate different electrical signals for the pairs of electrodes, a signal routing module to store signal routing information necessary to cause a physiological response in a user and to cause the signals to be delivered accordingly, and a configuration module for monitoring and updating the signal routing information based on information detected or received by the nerve stimulation system.
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公开(公告)号：US20200306534A1
公开(公告)日：2020-10-01
申请号：US16619392
申请日：2018-12-20
Applicant: Galvani Bioelectronics Limited
Abstract: A system for stimulation of a nerve and measuring impedance. The system includes a neural interface device including a plurality of electrodes; a voltage or current source operatively connected to at least a subset of the electrodes, wherein the voltage or current source is configured to generate an electrical signal to be applied to the electrodes; an impedance measuring module operatively connected to at least a subset of the electrodes, wherein the impedance measurement module is configured to measure the impedance between the electrodes; and a controller arranged to determine an amplitude of an action potential induced in the nerve, via the electrical signal, based on the measured impedance and to adjust the electrical signal in order to induce an action potential having a target amplitude.
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Patent Agency Ranking
4.发明公开公开(公告)号：US20240299737A1
公开(公告)日：2024-09-12
申请号：US18573365
申请日：2022-06-23
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Rizwan BASHIRULLAH , Gerald Edwin HUNSBERGER
IPC: A61N1/05
CPC classification number: A61N1/0558
Abstract: Stents for intravascular neural stimulation are disclosed herein that at least partially contact a vessel wall. The stent comprises a scaffold extending in a longitudinal direction and having an outer perimeter that at least partially contacts the wall. A pulse generator can generate electrical signals for delivery to a nerve for intravascular neural stimulation. The scaffold has mounted thereon a first set of one or more electrodes electrically coupled to the pulse generator. The stent further comprises a second set of one or more electrodes electrically coupled to the pulse generator. The second set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. Methods of implanting a stent into a vessel using a deployment catheter are disclosed herein. The stent to be implanted comprises a pulse generator, a scaffold, and a distal set of one or more electrodes electrically coupled to the pulse generator. The distal set of electrodes is unconnected to the scaffold, i.e. not directly mounted on the scaffold. The method comprises positioning a distal end of the deployment catheter at the intravascular location, advancing the stent within the deployment catheter, further advancing the stent to expose the one or more electrodes of the distal set of one or more electrodes outside of, preferably beyond the deployment catheter, providing an electrical stimulation via the exposed electrodes, and withdrawing the stent within the deployment catheter.
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公开(公告)号：US20180131415A1
公开(公告)日：2018-05-10
申请号：US15803405
申请日：2017-11-03
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan BASHIRULLAH
CPC classification number: H04B5/0075 , A61B5/0026 , A61B5/0031 , A61B5/04001 , A61B2560/0219 , A61M2205/3538 , A61M2205/3569 , A61N1/3605
Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.
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公开(公告)号：US20180126015A1
公开(公告)日：2018-05-10
申请号：US15803496
申请日：2017-11-03
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan BASHIRULLAH
CPC classification number: A61K51/1282 , G21H1/02 , H02H9/002
Abstract: An implantable system is disclosed that includes an encapsulated housing including a radioactive source. The encapsulated housing is internally coated with a light-generating coating that converts the radioactive energy to light, that is then output in vivo to a photodiode positioned proximate to at least part of the encapsulated housing in vivo. The photodiode is configured to generate electrical current from the light, which electrical current is output to a power conditioning circuit that is configured to use the electrical current as an input electrical current and to output power to a load in vivo. The encapsulated may also be internally coated, at least in part, with a light directing coating that causes light to be directed toward an optical lens that focuses the light on the photodiode. The radioactive source may be a gas having a low half-life and which poses no health risk to a patient if released.
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公开(公告)号：US20230241396A1
公开(公告)日：2023-08-03
申请号：US18002179
申请日：2021-06-18
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Michael John CARR , Rizwan BASHIRULLAH
CPC classification number: A61N1/36139 , A61N1/36153 , A61N1/0556 , A61N1/36053
Abstract: The present invention provides an implantable neuromodulation system for delivering an electrical signal to a nerve to stimulate, inhibit or block conduction of action potentials in the nerve. The system comprises a neural interface device comprising first and second electrodes; a signal generator and a first closed-loop controller configured to generate a control signal based a property of the signal based on a measured voltage across the first and second electrodes, and cause the signal generator to adjust the electrical signal to modify the property of the signal.
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公开(公告)号：US20210154485A1
公开(公告)日：2021-05-27
申请号：US17164350
申请日：2021-02-01
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan BASHIRULLAH
Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device
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