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公开(公告)号：US07709486B2
公开(公告)日：2010-05-04
申请号：US12182044
申请日：2008-07-29
申请人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61P19/02 , A61P1/00 , A61P35/00 , A61K31/497 , A61K31/395 , A61K31/33 , A61K31/44 , A61K31/675 , C07D257/02 , C07D487/08
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US07414065B2
公开(公告)日：2008-08-19
申请号：US10991944
申请日：2004-11-17
申请人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary J. Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K31/395 , C07D257/02 , A61P19/02
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV或FIV感染的细胞的标准测试中具有活性的单环多胺的衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US06506770B1
公开(公告)日：2003-01-14
申请号：US09111895
申请日：1998-07-08
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K3144
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US07022717B2
公开(公告)日：2006-04-04
申请号：US10703781
申请日：2003-11-07
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61P9/10 , A61K31/44 , C07D245/00 , C07D255/00
CPC分类号： C07D401/12 , A61K31/33 , A61K31/4439 , A61K31/496 , A61K31/52 , C07D257/02 , C07D403/12 , C07D413/12 , C07D417/12 , Y02A50/411
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
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公开(公告)号：US06756391B2
公开(公告)日：2004-06-29
申请号：US10143692
申请日：2002-05-09
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K31675
CPC分类号： C07D473/00 , C04B35/632 , C07D257/02 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/06
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
摘要翻译： 本发明涉及新的抗病毒化合物，药物组合物及其应用。 更具体地，本发明涉及在针对HIV感染细胞的标准测试中具有活性的单环多胺衍生物以及与介导多种哺乳动物胚胎发育过程的配体与趋化因子受体的结合相关的其它生物活性。
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公开(公告)号：US06667320B2
公开(公告)日：2003-12-23
申请号：US09740050
申请日：2000-12-15
申请人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
发明人： Gary James Bridger , Eva Maria Boehringer , Zhongren Wang , Dominique Schols , Renato Tony Skerlj , David Earl Bogucki
IPC分类号： A61K3144
CPC分类号： C07D401/12 , A61K31/33 , A61K31/4439 , A61K31/496 , A61K31/52 , C07D257/02 , C07D403/12 , C07D413/12 , C07D417/12 , Y02A50/411
摘要： The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
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