公开(公告)号：US12239664B2

公开(公告)日：2025-03-04

申请号：US17703927

申请日：2022-03-24

Applicant: Genentech, Inc.

Inventor： Sascha Rutz ,  Benjamin Joseph Haley ,  Shravan Madireddi ,  Soyoung Oh ,  David Shaw ,  Kate Halliwell Senger

IPC: A61K35/17 ,  A61K38/00 ,  C07K14/725 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/11 ,  C12N15/62 ,  C12N15/90

Abstract: The present disclosure relates to engineered T cells and methods of making and using the same, as well as reagents for making the engineered T cells.

公开(公告)号：US20230041268A1

公开(公告)日：2023-02-09

申请号：US17703927

申请日：2022-03-24

Applicant: Genentech, Inc.

Inventor： Sascha Rutz ,  Benjamin Joseph Haley ,  Shravan Madireddi ,  Soyoung Oh ,  David Shaw ,  Kate Halliwell Senger

IPC: A61K35/17 ,  C12N5/0783 ,  C12N15/11 ,  C12N9/22 ,  C12N15/90 ,  C12N15/62 ,  C07K14/725

Abstract: The present disclosure relates to engineered T cells and methods of making and using the same, as well as reagents for making the engineered T cells.

公开(公告)号：US12205386B2

公开(公告)日：2025-01-21

申请号：US17841610

申请日：2022-06-15

Applicant: Genentech, Inc.

Inventor： Zheng Li ,  Mandy Man Chu Yim ,  Bibi Ephraim ,  Dat Tran ,  Xinyu Liu ,  David Shaw

IPC: G06V20/69 ,  G06T7/00 ,  G06T7/11 ,  G06T7/73 ,  G06V10/25 ,  G06V10/44 ,  G06V10/82

Abstract: A method includes, by a computing system, receiving a querying image depicting a sampling area, processing the querying image using a single cluster detection model to identify one or more regions of the querying image depicting a cluster in the sampling area, processing the one or more regions using a cluster verification deep-learning model to determine whether each depicted cluster is a cell cluster, and determining that exactly one of the identified one or more regions depicts a cluster that is a cell cluster. The method further includes processing the region depicting the cell cluster using a morphology deep-learning model to determine that there is only one cell in the cell cluster and to determine that die morphology of the cell is acceptable.