公开(公告)号：US20160185864A1

公开(公告)日：2016-06-30

申请号：US14813669

申请日：2015-07-30

Applicant: Genentech, Inc.

Inventor： Dorothy FRENCH

IPC: C07K16/28 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K39/395 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/57484 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2333/71 ,  G01N2333/96494

Abstract: Provided herein are biomarkers and therapies for the treatment of pathological conditions, such as cancer, and method of using FGFR3 antagonists. In particular, provided is FGFR3 as a biomarker for patient selection and prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

Abstract translation: 本文提供了用于治疗诸如癌症的病理状况的生物标志物和疗法，以及使用FGFR3拮抗剂的方法。 特别地，提供了FGFR3作为癌症患者选择和预后的生物标志物，以及治疗性治疗方法，制造方法及其制备方法，诊断试剂盒，检测方法和与之相关的广告方法。

公开(公告)号：US20150266953A1

公开(公告)日：2015-09-24

申请号：US14581971

申请日：2014-12-23

Applicant: GENENTECH, INC.

Inventor： Jian CHEN ,  Ellen FILVAROFF ,  Sherman FONG ,  Dorothy FRENCH ,  Audrey GODDARD ,  Paul J. GODOWSKI ,  J. Christopher GRIMALDI ,  Austin L. GUMEY ,  Kenneth J. HILLAN ,  Sarah G. HYMOWITZ ,  Hanzhong LI ,  James Pan ZTUBICOKE ,  Melissa A. STAROVASNIK ,  Daniel TUMAS ,  Menno VAN LOOKEREN ,  Richard VANDLEN ,  Colin K. WATANABE ,  P. Mickey WILLIAMS ,  William I. WOOD ,  Daniel G. YANSURA

IPC: C07K16/24 ,  C07K14/54

CPC classification number: C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

公开(公告)号：US20160237157A1

公开(公告)日：2016-08-18

申请号：US14995111

申请日：2016-01-13

Applicant: Genentech, Inc.

Inventor： Mark DENNIS ,  Luc DESNOYERS ,  Dorothy FRENCH

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides anti-FGFR4 antibodies and methods of using the same.

Abstract translation: 本发明提供抗FGFR4抗体及其使用方法。

公开(公告)号：US20150141283A1

公开(公告)日：2015-05-21

申请号：US14489167

申请日：2014-09-17

Applicant: GENENTECH, INC.

Inventor： Jian CHEN ,  Ellen FILVAROFF ,  Sherman FONG ,  Dorothy FRENCH ,  Audrey GODDARD ,  Paul J. GODOWSKI ,  J. Christopher GRIMALDI ,  Austin L. GURNEY ,  Kenneth J. HILIAN ,  Sarah G. HYMOWITZ ,  Hanzhong LI ,  Melissa A. STAROVASNIK ,  Daniel TUMAS ,  Menno VAN LOOKEREN ,  Richard VANDLEN ,  Colin K. WATANABE ,  P. Mickey WILLIAMS ,  William I. WOOD ,  Daniel G. YANSURA ,  James PAN

IPC: G01N33/574

CPC classification number: C07K16/244 ,  A61K38/00 ,  C07H21/04 ,  C07K14/54 ,  C07K14/7155 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/35 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/62 ,  G01N33/505 ,  G01N33/564 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57492 ,  G01N2333/54 ,  G01N2333/7155

Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.