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公开(公告)号：US20210395384A1
公开(公告)日：2021-12-23
申请号：US17198199
申请日：2021-03-10
Applicant: Genmab A/S
Inventor： David SATJIN , Sandra VERPLOEGEN , Wim BLEEKER , Steen LISBY , Jan VAN DE WINKEL , Patrick VAN BERKEL , Paul PARREN
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
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公开(公告)号：US20200048304A1
公开(公告)日：2020-02-13
申请号：US16426647
申请日：2019-05-30
Applicant: GENMAB A/S
Inventor： Michael GRAMER , Amitava KUNDU , Ewald T. J. VAN DEN BREMER , Muriel VAN KAMPEN , Patrick PRIEM , Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Janine SCHUURMAN , Paul PARREN , Patrick VAN BERKEL , Werner L. VOS , Arnout F. GERRITSEN
Abstract: The present invention relates to an in vitro method for production of heterodimeric proteins.
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公开(公告)号：US20170362319A1
公开(公告)日：2017-12-21
申请号：US15414254
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Catharina Emanuele GERARDA HAVENITH , Tom VINK , Patrick VAN BERKEL , Paul PARREN
IPC: C07K16/28 , G01N33/566
CPC classification number: C07K16/2812 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/732 , C07K2317/76 , G01N33/566 , G01N2333/70535
Abstract: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
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公开(公告)号：US20170233497A1
公开(公告)日：2017-08-17
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Ewald T. J. VAN DEN BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
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5.发明申请TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 审中-公开生产从这些动物获得的单一人类抗体和抗体的转基因动物公开(公告)号：US20170037138A1
公开(公告)日：2017-02-09
申请号：US15072983
申请日：2016-03-17
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Tom VINK , Jan VAN DE WINKEL , Aran Frank LABRIJN , Paul PARREN , Willem Karel BLEEKER , Frank BEURSKENS , Patrick VAN BERKEL
IPC: C07K16/28
CPC classification number: C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Abstract translation: 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
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Patent Agency Ranking
公开(公告)号：US20250066506A1
公开(公告)日：2025-02-27
申请号：US18596319
申请日：2024-03-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Patrick VAN BERKEL , Kristin STRUMANE , Aran Frank LABRIJN , Joost J. NEIJSSEN , Joyce I. MEESTERS , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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公开(公告)号：US20240294661A1
公开(公告)日：2024-09-05
申请号：US18526959
申请日：2023-12-01
Applicant: Genmab A/S
Inventor： David SATIJN , Sandra VERPLOEGEN , Wim BLEEKER , Steen LISBY , Jan VAN DE WINKEL , Patrick VAN BERKEL , Paul PARREN
CPC classification number: C07K16/30 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.
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公开(公告)号：US20220177585A1
公开(公告)日：2022-06-09
申请号：US17349482
申请日：2021-06-16
Applicant: GENMAB A/S
Inventor： Catharina Emanuele GERARDA HAVENITH , Tom VINK , Patrick VAN BERKEL , Paul PARREN
IPC: C07K16/28 , G01N33/566
Abstract: The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
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公开(公告)号：US20160067349A1
公开(公告)日：2016-03-10
申请号：US14854613
申请日：2015-09-15
Applicant: GENMAB A/S
Inventor： David SATIJN , Sandra VERPLOEGEN , Wim BLEEKER , Steen LISBY , Jan VAN DE WINKEL , Patrick VAN BERKEL , Paul PARREN
CPC classification number: A61K47/48561 , A61K45/06 , A61K47/6817 , A61K47/6849 , C07K16/30 , C07K16/36 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.
Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。
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公开(公告)号：US20240209117A1
公开(公告)日：2024-06-27
申请号：US18507869
申请日：2023-11-13
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Edwald T. J. VAN DER BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , G01N33/6854 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
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