公开(公告)号：US20210395384A1

公开(公告)日：2021-12-23

申请号：US17198199

申请日：2021-03-10

Applicant: Genmab A/S

Inventor： David SATJIN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: C07K16/30 ,  C07K16/36 ,  A61K47/68 ,  A61K45/06

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20190030178A1

公开(公告)日：2019-01-31

申请号：US15758520

申请日：2016-09-09

Applicant: GENMAB A/S

Inventor： Steen LISBY ,  Nancy Cherry WHITING

IPC: A61K47/68 ,  A61K38/07 ,  C07K16/36

Abstract: Anti-TF antibody drug conjugate and pharmaceutical compositions comprising the antibody drug-conjugate for use in the treatment of a solid cancer comprising administering to a subject a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an anti-TF antibody drug conjugate once a week for three consecutive weeks followed by a one week resting period without any administration of anti-TF ADC so that each cycle time is 28 days including the resting period.

公开(公告)号：US20220265844A1

公开(公告)日：2022-08-25

申请号：US17548436

申请日：2021-12-10

Applicant: Genmab A/S

Inventor： Steen LISBY ,  Nancy Cherry WHITING

IPC: A61K47/68 ,  A61K38/07 ,  C07K16/36

Abstract: Anti-TF antibody drug conjugate and pharmaceutical compositions comprising the antibody drug-conjugate for use in the treatment of a solid cancer comprising administering to a subject a weekly dose of from about 0.8 mg/kg to about 1.8 mg/kg of an anti-TF antibody drug conjugate once a week for three consecutive weeks followed by a one week resting period without any administration of anti-TF ADC so that each cycle time is 28 days including the resting period.

公开(公告)号：US20170136130A1

公开(公告)日：2017-05-18

申请号：US15277626

申请日：2016-09-27

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: A61K39/00 ,  C07K16/36 ,  A61K45/06

CPC classification number: C07K16/30 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20240294661A1

公开(公告)日：2024-09-05

申请号：US18526959

申请日：2023-12-01

Applicant: Genmab A/S

Inventor： David SATIJN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: C07K16/30 ,  A61K45/06 ,  A61K47/68 ,  C07K16/36

CPC classification number: C07K16/30 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

公开(公告)号：US20240252673A1

公开(公告)日：2024-08-01

申请号：US18451780

申请日：2023-08-17

Applicant: Genmab A/S

Inventor： Reshma A. RANGWALA ,  Steen LISBY

IPC: A61K47/68 ,  A61K9/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  A61K39/00

CPC classification number: A61K47/6869 ,  A61K9/0019 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6811 ,  A61P35/00 ,  A61P35/04 ,  C07K16/32 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/565

Abstract: The invention provides methods and compositions for treating cancer, such as advanced cervical cancer, in a subject, such as by the administration of antibody-drug conjugates that bind to tissue factor (TF). The invention also provides articles of manufacture and compositions comprising said antibody drug-conjugates that bind to TF for use in treating cancer (e.g., advanced cervical cancer).

公开(公告)号：US20240165226A1

公开(公告)日：2024-05-23

申请号：US18488634

申请日：2023-10-17

Applicant: GENMAB A/S

Inventor： Jan VAN DE WINKEL ,  Paul PARREN ,  Yvo GRAUS ,  Judith OPRINS ,  Michel DE WEERS ,  Martine VAN VUGT ,  Ole BAADSGAARD ,  Steen LISBY

IPC: A61K39/395 ,  A61K31/198 ,  A61K31/4439 ,  A61K31/573 ,  A61K31/69 ,  A61K45/06 ,  A61P19/02 ,  A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K31/198 ,  A61K31/4439 ,  A61K31/573 ,  A61K31/69 ,  A61K39/39558 ,  A61K45/06 ,  A61P19/02 ,  A61P35/00 ,  C07K16/2896 ,  A61K2039/505 ,  C07K2317/34

Abstract: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.

公开(公告)号：US20160067349A1

公开(公告)日：2016-03-10

申请号：US14854613

申请日：2015-09-15

Applicant: GENMAB A/S

Inventor： David SATIJN ,  Sandra VERPLOEGEN ,  Wim BLEEKER ,  Steen LISBY ,  Jan VAN DE WINKEL ,  Patrick VAN BERKEL ,  Paul PARREN

IPC: A61K47/48 ,  C07K16/30 ,  A61K45/06

CPC classification number: A61K47/48561 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6849 ,  C07K16/30 ,  C07K16/36 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.

Abstract translation: 针对组织因子的抗体药物偶联物。 还公开了包含抗体和抗体药物共轭物的药物组合物，以及使用抗体和抗体药物偶联物的治疗和诊断方法。

公开(公告)号：US20150231235A1

公开(公告)日：2015-08-20

申请号：US14566279

申请日：2014-12-10

Applicant: GENMAB A/S

Inventor： Jan VAN DE WINKEL ,  Paul PARREN ,  Yvo GRAUS ,  Judith OPRINS ,  Michel DE WEERS ,  Martine VAN VUGT ,  Ole BAADSGAARD, D.M.Sc. ,  Steen LISBY

IPC: A61K39/395 ,  A61K31/4439 ,  A61K31/198 ,  A61K31/573 ,  A61K31/69

Abstract: The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.

Abstract translation: 本发明涉及使用包含结合CD38的抗体，皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。

公开(公告)号：US20220323582A1

公开(公告)日：2022-10-13

申请号：US17502774

申请日：2021-10-15

Applicant: GENMAB A/S

Inventor： Sandra VERPLOEGEN ,  Marije OVERDIJK ,  Riemke VAN DIJKHUIZEN ,  Willem Karel BLEEKER ,  Patrick VAN BERKEL ,  Paul PARREN ,  Steen LISBY

IPC: A61K39/395 ,  A61K51/10 ,  C07K16/28 ,  A61K47/68 ,  A61K31/7088 ,  A61K35/17 ,  A61K35/76 ,  A61K38/16 ,  A61K38/19 ,  A61K45/06 ,  C07K16/18

Abstract: Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.