公开(公告)号：US20210171987A1

公开(公告)日：2021-06-10

申请号：US17074017

申请日：2020-10-19

Applicant: Genomatica, Inc.

Inventor： Jay D. KEASLING ,  Zhihao HU ,  Chris SOMERVILLE ,  George CHURCH ,  David BERRY ,  Lisa C. FRIEDMAN ,  Andreas SCHIRMER ,  Shane BRUBAKER ,  Stephen B. DEL CARDAYRE

IPC: C12P7/04 ,  C10L1/02 ,  C10L1/32 ,  C12P7/64 ,  C07C31/125 ,  C07C33/02

Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.

公开(公告)号：US20230159901A1

公开(公告)日：2023-05-25

申请号：US17834681

申请日：2022-06-07

Applicant: Genomatica, Inc.

Inventor： Andreas SCHIRMER ,  Baolong ZHU ,  Emanuela POPOVA

IPC: C12N9/04 ,  C12N15/62 ,  C12N9/02 ,  C12N15/81

CPC classification number: C12N9/0006 ,  C12N15/62 ,  C12N9/0042 ,  C12N15/81 ,  C07K2319/00 ,  C12N9/18

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20220090028A1

公开(公告)日：2022-03-24

申请号：US17405685

申请日：2021-08-18

Applicant: Genomatica, Inc.

Inventor： Mathew RUDE ,  Na TRINH ,  Andreas SCHIRMER ,  Jacob GANO

IPC: C12N9/02 ,  C12P7/24 ,  C12P7/04 ,  C12P7/64

Abstract: The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.