公开(公告)号：US20230159901A1

公开(公告)日：2023-05-25

申请号：US17834681

申请日：2022-06-07

Applicant: Genomatica, Inc.

Inventor： Andreas SCHIRMER ,  Baolong ZHU ,  Emanuela POPOVA

IPC: C12N9/04 ,  C12N15/62 ,  C12N9/02 ,  C12N15/81

CPC classification number: C12N9/0006 ,  C12N15/62 ,  C12N9/0042 ,  C12N15/81 ,  C07K2319/00 ,  C12N9/18

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20210230562A1

公开(公告)日：2021-07-29

申请号：US17001015

申请日：2020-08-24

Applicant: Genomatica, Inc.

Inventor： Andreas Schirmer ,  Baolong ZHU ,  Emanuela Popova

IPC: C12N9/04 ,  C12N15/62 ,  C12N9/02 ,  C12N15/81

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20250019731A1

公开(公告)日：2025-01-16

申请号：US18595947

申请日：2024-03-05

Applicant: Genomatica, Inc.

Inventor： Andreas W. SCHIRMER ,  Haibo WANG ,  Stephen B. DEL CARDAYRE ,  Zhihao HU ,  Louis G. HOM ,  Baolong ZHU ,  Cindy CHANG ,  Emanuela E. POPOVA

IPC: C12P7/6409 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US20230167419A1

公开(公告)日：2023-06-01

申请号：US17818038

申请日：2022-08-08

Applicant: Genomatica, Inc.

Inventor： Baolong ZHU ,  Andreas W. Schirmer ,  Cindy Chang

IPC: C12N9/02 ,  C12P7/6409

CPC classification number: C12N9/0077 ,  C12P7/6409

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for ex pressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20200370024A1

公开(公告)日：2020-11-26

申请号：US16661667

申请日：2019-10-23

Applicant: Genomatica, Inc.

Inventor： Baolong ZHU ,  Andreas W. Schirmer ,  Cindy CHANG

IPC: C12N9/02 ,  C12P7/64

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.