公开(公告)号：US20230159901A1

公开(公告)日：2023-05-25

申请号：US17834681

申请日：2022-06-07

Applicant: Genomatica, Inc.

Inventor： Andreas SCHIRMER ,  Baolong ZHU ,  Emanuela POPOVA

IPC: C12N9/04 ,  C12N15/62 ,  C12N9/02 ,  C12N15/81

CPC classification number: C12N9/0006 ,  C12N15/62 ,  C12N9/0042 ,  C12N15/81 ,  C07K2319/00 ,  C12N9/18

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20250059524A1

公开(公告)日：2025-02-20

申请号：US18937302

申请日：2024-11-05

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/6409 ,  C12P7/6436

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

公开(公告)号：US20220243185A1

公开(公告)日：2022-08-04

申请号：US17715587

申请日：2022-04-07

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/6409

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

公开(公告)号：US20210207111A1

公开(公告)日：2021-07-08

申请号：US16500188

申请日：2018-04-03

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/64

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.