公开(公告)号：US20210009983A1

公开(公告)日：2021-01-14

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. GREENFIELD ,  Donald E. TRIMBUR ,  Andreas W. SCHIRMER ,  Cindy CHANG ,  Behnaz BEHROUZIAN ,  Jessica WINGER

IPC: C12N9/00 ,  C07K14/245 ,  C12P7/64

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US20250059524A1

公开(公告)日：2025-02-20

申请号：US18937302

申请日：2024-11-05

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/6409 ,  C12P7/6436

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

公开(公告)号：US20220243185A1

公开(公告)日：2022-08-04

申请号：US17715587

申请日：2022-04-07

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/6409

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.

公开(公告)号：US20210207111A1

公开(公告)日：2021-07-08

申请号：US16500188

申请日：2018-04-03

Applicant: Genomatica, Inc.

Inventor： Angelica Zabala BAUTISTA ,  Min Sun PARK ,  Alma Itzel RAMOS-SOLIS ,  Bernardo Moura TORRES DA COSTA ,  Behnaz BEHROUZIAN ,  Donald E. TRIMBUR ,  Emanuela POPOVA ,  Qijun HU ,  Stephen Bralley DEL CARDAYRE

IPC: C12N9/16 ,  C12P7/64

Abstract: The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives. The disclosure further relates to recombinant host cells comprising the engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives. The disclosure also relates to methods of decreasing toxicity and improving production of medium-chain fatty acids and derivatives.