Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels

    公开(公告)号:US20220081669A1

    公开(公告)日:2022-03-17

    申请号:US17456504

    申请日:2021-11-24

    Inventor: Robert Snow

    Abstract: Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process. The isolation processes described herein allow for continuous removal of fluid streams (e.g., waste streams, liquid containing recombinant therapeutic proteins) from a sterilized system (e.g., a biological manufacturing system), which provides for less manual manipulation of the sterilized system and a decreased risk of contaminating the sterilized system.

    IN-LINE PRODUCT MONITORING IN INTEGRATED CONTINUOUS BIO-MANUFACTURING

    公开(公告)号:US20210115385A1

    公开(公告)日:2021-04-22

    申请号:US17076064

    申请日:2020-10-21

    Abstract: Methods for controlling a biological manufacturing system include directing a light beam to pass through a wall of a vessel containing a first fluid generated by the biological manufacturing system, measuring an angle of refraction of the light beam in the first fluid, the angle of refraction corresponding to an angle between a propagation direction of the light beam in the first fluid and a normal to an interface between the vessel wall and the first fluid, determining information about the first fluid based on the measured angle of refraction, and adjusting a parameter of the biological manufacturing system based on the information about the first fluid.

    Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels

    公开(公告)号:US20210002601A1

    公开(公告)日:2021-01-07

    申请号:US17027017

    申请日:2020-09-21

    Inventor: Robert Snow

    Abstract: Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process. The isolation processes described herein allow for continuous removal of fluid streams (e.g., waste streams, liquid containing recombinant therapeutic proteins) from a sterilized system (e.g., a biological manufacturing system), which provides for less manual manipulation of the sterilized system and a decreased risk of contaminating the sterilized system.

    Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels
    4.
    发明申请
    Integrated Continuous Isolation of Fluid Streams From Sterile Process Vessels 审中-公开
    从无菌过程容器中流体流的一体化连续分离

    公开(公告)号:US20160115438A1

    公开(公告)日:2016-04-28

    申请号:US14918107

    申请日:2015-10-20

    Inventor: Robert Snow

    Abstract: Provided herein are isolation processes and the associated hardware to allow fluid streams to be isolated from a sterilized system (e.g., a sterile process vessel) that contains a sterile process. The isolation processes described herein allow for continuous removal of fluid streams (e.g., waste streams, liquid containing recombinant therapeutic proteins) from a sterilized system (e.g., a biological manufacturing system), which provides for less manual manipulation of the sterilized system and a decreased risk of contaminating the sterilized system.

    Abstract translation: 本文提供了隔离过程和相关联的硬件,以允许流体流与包含无菌过程的灭菌系统(例如,无菌处理容器)分离。 本文所述的分离过程允许从灭菌系统(例如,生物制造系统)连续去除流体物流(例如,含有重组治疗蛋白的液体),其提供对手术操作无菌系统的较少量和减少的 污染无菌系统的风险。

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