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公开(公告)号：US20060217435A1
公开(公告)日：2006-09-28
申请号：US11276247
申请日：2006-02-21
申请人： Kai Gerlach , Henning Priepke , Roland Pfau , Georg Dahmann , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar
发明人： Kai Gerlach , Henning Priepke , Roland Pfau , Georg Dahmann , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar
CPC分类号： C07D207/273 , C07D405/12 , C07D409/04 , C07D409/14
摘要： The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式的新的取代的吡咯烷酮，其中A，X，B和R 1至R 9如权利要求1所定义，互变异构体，对映异构体， 非对映异构体，其混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的性质。
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2.发明授权公开(公告)号：US08791103B2
公开(公告)日：2014-07-29
申请号：US13866255
申请日：2013-04-19
申请人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
发明人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
IPC分类号： A01N43/62 , A61K31/55 , C07D223/00
CPC分类号： C07D471/04 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/26 , C07D235/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式的新的取代的羧酸酰胺，其中A，B和R 1至R 5如权利要求1所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐，特别是生理上可接受的盐 具有有价值的性质的无机或有机酸或碱。
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3.发明申请New carboxylic acid amides, the preparation thereof and their use as medicaments 有权新的羧酸酰胺，其制备及其作为药物的用途公开(公告)号：US20050203078A1
公开(公告)日：2005-09-15
申请号：US11056413
申请日：2005-02-11
申请人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
发明人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
IPC分类号： C07D235/10 , C07D235/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , A61K31/553 , A61K31/551 , A61K31/554
CPC分类号： C07D471/04 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/26 , C07D235/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式如下的新的取代的羧酸酰胺，其中A，B和R 1至R 5定义如权利要求1所述，互变异构体，对映异构体， 非对映异构体，其混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的性质。
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4.发明授权公开(公告)号：US07615549B2
公开(公告)日：2009-11-10
申请号：US11275187
申请日：2005-12-16
申请人： Kai Gerlach , Henning Priepke , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Peter Kuehn , Georg Dahmann
发明人： Kai Gerlach , Henning Priepke , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Peter Kuehn , Georg Dahmann
IPC分类号： A61K31/55 , A61K31/5377 , A61K31/445 , C07D267/10 , C07D265/32 , C07D295/00 , C07D401/14
CPC分类号： C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , C07D419/14
摘要： The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are as defined above, or a tautomer or salt thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及以下通式的新的取代的吡咯烷酮：其中A，X，B和R 1至R 9如上所定义，或其互变异构体或其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的 属性。
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5.发明申请NEW CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS 有权新型羧酸酰胺，其制剂及其作为药物使用公开(公告)号：US20080146539A1
公开(公告)日：2008-06-19
申请号：US11960222
申请日：2007-12-19
申请人： Henning PRIEPKE , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
发明人： Henning PRIEPKE , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
IPC分类号： A61K31/553 , C07D487/04 , A61K31/551 , C12N9/99 , A61K31/55
CPC分类号： C07D471/04 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/26 , C07D235/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式如下的新的取代的羧酸酰胺，其中A，B和R 1至R 5定义如权利要求1所述，互变异构体，对映异构体， 非对映异构体，其混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的性质。
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6.发明授权公开(公告)号：US07371743B2
公开(公告)日：2008-05-13
申请号：US11056413
申请日：2005-02-11
申请人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
发明人： Henning Priepke , Kai Gerlach , Roland Pfau , Norbert Hauel , Iris Kauffmann-Hefner , Georg Dahmann , Herbert Nar , Sandra Handschuh , Wolfgang Wienen , Annette Schuler-Metz
IPC分类号： C07D279/00 , A61K31/55
CPC分类号： C07D471/04 , A61K9/02 , A61K9/2018 , A61K9/4858 , A61K47/26 , C07D235/14 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式如下的新的取代的羧酸酰胺，其中A，B和R 1至R 5定义如权利要求1所述，互变异构体，对映异构体， 非对映异构体，其混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，其具有有价值的性质。
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7.发明授权Substituted glycinamides, process for their manufacture and use thereof as medicaments 有权取代的甘氨酰胺，其制备方法和用途作为药物公开(公告)号：US09062034B2
公开(公告)日：2015-06-23
申请号：US13785176
申请日：2013-03-05
申请人： Henning Priepke , Georg Dahmann , Kai Gerlach , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Sandra Handschuh , Herbert Nar
发明人： Henning Priepke , Georg Dahmann , Kai Gerlach , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Sandra Handschuh , Herbert Nar
IPC分类号： A61K31/55 , C07D407/14 , C07D409/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
CPC分类号： C07D487/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08
摘要： The present invention relates to new substituted glycinamides of general formula (I) wherein D, M, R3, R4 and R5 are defined as in the specification, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式（I）的新的取代的甘氨酰胺，其中D，M，R 3，R 4和R 5如说明书中所定义，其互变异构体，对映异构体，非对映体，其混合物和盐，特别是其生理上可接受的盐与 无机或有机酸或碱，具有有价值的性质。
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8.发明授权公开(公告)号：US07732466B2
公开(公告)日：2010-06-08
申请号：US11125734
申请日：2005-05-10
申请人： Roland Pfau , Henning Priepke , Kai Gerlach , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Sandra Handschuh , Georg Dahmann
发明人： Roland Pfau , Henning Priepke , Kai Gerlach , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Sandra Handschuh , Georg Dahmann
IPC分类号： A01N43/36 , A61K31/44 , A01N43/50 , C07D487/04 , C07D401/00
CPC分类号： C07D333/38 , C07D409/12 , C07D409/14 , C07D417/12
摘要： The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式的新的取代的噻吩-2-羧酸酰胺，其中A和R 1至R 8c如权利要求1中所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐，特别是 其生理上可接受的盐与具有有价值性质的无机或有机酸或碱形成。
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公开(公告)号：US07714000B2
公开(公告)日：2010-05-11
申请号：US11276247
申请日：2006-02-21
申请人： Kai Gerlach , Henning Priepke , Roland Pfau , Georg Dahmann , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar
发明人： Kai Gerlach , Henning Priepke , Roland Pfau , Georg Dahmann , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar
IPC分类号： A61K31/40 , C07D401/04
CPC分类号： C07D207/273 , C07D405/12 , C07D409/04 , C07D409/14
摘要： The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及通式的新的取代的吡咯烷酮，其中A，X，B和R 1至R 9如权利要求1所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐，特别是生理上可接受的盐 具有有价值的性质的无机或有机酸或碱。
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10.发明申请NEW SUBSTITUTED PYRROLIDINONES, THEIR MANUFACTURE AND THEIR USE AS MEDICAMENTS 有权新的替代吡咯烷酮，其制造及其作为药物使用公开(公告)号：US20060142263A1
公开(公告)日：2006-06-29
申请号：US11275187
申请日：2005-12-16
申请人： Kai Gerlach , Henning Priepke , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Peter Kuehn , Georg Dahmann
发明人： Kai Gerlach , Henning Priepke , Roland Pfau , Wolfgang Wienen , Annette Schuler-Metz , Herbert Nar , Peter Kuehn , Georg Dahmann
IPC分类号： A61K31/554 , A61K31/551 , A61K31/549 , A61K31/501 , A61K31/497 , A61K31/496 , A61K31/4545 , A61K31/444 , C07D417/02 , C07D403/02
CPC分类号： C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , C07D419/14
摘要： The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are as defined above, or a tautomer or salt thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
摘要翻译： 本发明涉及以下通式的新的取代吡咯烷酮：其中A，X，B和R 1至R 9如上定义，或其互变异构体或盐，特别是 其生理上可接受的盐与无机或有机酸或碱具有有价值的性质。
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