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1.发明申请METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 审中-公开用于合成受约束的肽，肽衍生物及其作为合成疫苗的用途的方法公开(公告)号：US20090324707A1
公开(公告)日：2009-12-31
申请号：US12499500
申请日：2009-07-08
IPC分类号： A61K39/002 , A61K9/127 , A61P31/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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2.发明申请METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 审中-公开用于合成受约束的肽，肽衍生物及其作为合成疫苗的用途的方法公开(公告)号：US20110008414A9
公开(公告)日：2011-01-13
申请号：US12499500
申请日：2009-07-08
IPC分类号： A61K39/002 , A61K9/127 , A61P31/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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3.发明授权公开(公告)号：US07569541B2
公开(公告)日：2009-08-04
申请号：US10559010
申请日：2004-06-02
IPC分类号： A61K38/12
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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