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1.发明申请METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 审中-公开用于合成受约束的肽，肽衍生物及其作为合成疫苗的用途的方法公开(公告)号：US20110008414A9
公开(公告)日：2011-01-13
申请号：US12499500
申请日：2009-07-08
IPC分类号： A61K39/002 , A61K9/127 , A61P31/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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2.发明授权公开(公告)号：US07569541B2
公开(公告)日：2009-08-04
申请号：US10559010
申请日：2004-06-02
IPC分类号： A61K38/12
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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3.发明申请METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 审中-公开用于合成受约束的肽，肽衍生物及其作为合成疫苗的用途的方法公开(公告)号：US20090324707A1
公开(公告)日：2009-12-31
申请号：US12499500
申请日：2009-07-08
IPC分类号： A61K39/002 , A61K9/127 , A61P31/00
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。
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公开(公告)号：US20060258564A1
公开(公告)日：2006-11-16
申请号：US10559010
申请日：2004-06-02
申请人： Gerd Pluschke , Ursula Kienl , John Robinson , Rinaldo Zurbriggen
发明人： Gerd Pluschke , Ursula Kienl , John Robinson , Rinaldo Zurbriggen
CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.
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5.发明授权Compositions and methods for the generation of protective immune responses against malaria 有权用于产生针对疟疾的保护性免疫应答的组合物和方法公开(公告)号：US07198791B2
公开(公告)日：2007-04-03
申请号：US10379417
申请日：2003-03-03
CPC分类号： A61K39/015 , A61K2039/55555 , A61K2039/6018 , Y02A50/412
摘要： The invention presents vaccine formulations comprising highly antigenic epitopes identified within the semi-conserved loop-I of domain III that are capable of eliciting parasite growth inhibitory antibodies. The cyclized or linear peptides can be applied by known adjuvants or be encapsulated by or attached onto the surface of liposomes or virosomes (IRIVs) which serve as human compatible antigen delivery systems. Both cyclized and linear versions of the peptide antigens are surprisingly effective in eliciting immune responses that are cross-reactive with parasite-expressed AMA-1.
摘要翻译： 本发明提供了包含能够诱导寄生虫生长抑制性抗体的在区III的半保守环I内鉴定的高抗原性表位的疫苗制剂。 环化或线性肽可以通过已知的佐剂施用或被包封或附着到作为人类相容的抗原递送系统的脂质体或病毒颗粒（IRIV）的表面上。 肽抗原的环化和线性形式在引发与寄生虫表达的AMA-1交叉反应的免疫应答方面令人惊奇地有效。
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6.发明授权Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections 失效用于检测炭疽芽孢杆菌和针对炭疽杆菌感染的疫苗的抗体公开(公告)号：US07901687B2
公开(公告)日：2011-03-08
申请号：US12226728
申请日：2007-04-27
CPC分类号： A61K39/07 , A61K47/646 , A61K2039/6081
摘要： The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
摘要翻译： 本发明涉及式1的寡糖的缀合物，其中R是与载体蛋白质的接头，并且任选地包含多达三个其它的糖类，其可用于疫苗接种，合成这种缀合物的方法，针对该抗原的抗体， 产生针对该抗原的单克隆抗体的杂交瘤，使用这些抗体检测炭疽芽孢杆菌的试验和包含这些抗体的试剂盒，以及用于预防炭疽杆菌感染的疫苗，其包含式1的寡糖的缀合物。单克隆抗体10 本发明选择性地结合炭疽杆菌，但不涉及相关细菌如枯草芽孢杆菌，蜡状芽孢杆菌和该组其他细菌如苏云金芽孢杆菌。
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7.发明申请Antibodies for the Detection of Bacillus Anthracis and Vaccine Against B. Anthracis Infections 失效用于检测炭疽芽孢杆菌和疫苗对抗炭疽杆菌感染的抗体公开(公告)号：US20090155299A1
公开(公告)日：2009-06-18
申请号：US12226728
申请日：2007-04-27
IPC分类号： A61K39/07 , C07K16/18 , C12N5/06 , G01N33/569 , C07K2/00
CPC分类号： A61K39/07 , A61K47/646 , A61K2039/6081
摘要： The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis.
摘要翻译： 本发明涉及式1的寡糖的缀合物，其中R是与载体蛋白质的接头，并且任选地包含多达三个其它的糖类，其可用于疫苗接种，合成这种缀合物的方法，针对该抗原的抗体， 产生针对该抗原的单克隆抗体的杂交瘤，使用这些抗体检测炭疽芽孢杆菌的试验和包含这些抗体的试剂盒，以及用于预防炭疽杆菌感染的疫苗，其包含式1的寡糖的缀合物。单克隆抗体10 本发明选择性地结合炭疽杆菌，但不涉及相关细菌如枯草芽孢杆菌，蜡状芽孢杆菌和该组其他细菌如苏云金芽孢杆菌。
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8.发明授权Antiidiotypic antibodies for high molecular weight-melanoma associated antigen 失效用于高分子量黑素瘤相关抗原的抗独特型抗体
公开(公告)号：US5866124A
公开(公告)日：1999-02-02
申请号：US650262
申请日：1996-05-22
申请人： Norman Hardman , Gerd Pluschke , Brendan Murray
发明人： Norman Hardman , Gerd Pluschke , Brendan Murray
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K16/00 , C07K16/32 , C07K16/42 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/91 , F02B75/02 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K16/4266 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2319/02 , C07K2319/50 , F02B2075/027 , Y10S435/81
摘要： The invention concerns antiidiotypic antibodies comprising human constant regions, and murine variable regions bearing the internal image of human high molecular weight-melanoma associated antigen which have the specificity of said antibody. These antiidiotypic monoclonal antibodies have immune-regulatory functions and can therefore be used for diagnostic and therapeutic purposes, such as the treatment of melanoma.
摘要翻译： PCT No.PCT / EP93 / 00505 Sec。 371日期：1994年9月14日 102（e）1994年9月14日PCT 1993年3月5日PCT公布。 公开号WO93 / 19180 PCT 日期1993年9月30日本发明涉及包含人恒定区的抗独特型抗体以及具有所述抗体特异性的人类高分子量 - 黑素瘤相关抗原的内部图像的鼠可变区。 这些抗独特型单克隆抗体具有免疫调节功能，因此可用于诊断和治疗目的，例如治疗黑素瘤。
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