公开(公告)号：US20130071381A1

公开(公告)日：2013-03-21

申请号：US13528407

申请日：2012-06-20

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/7158 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2319/00

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20080241136A1

公开(公告)日：2008-10-02

申请号：US11924794

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20080268536A1

公开(公告)日：2008-10-30

申请号：US11924091

申请日：2007-10-25

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： C12N5/06

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。

公开(公告)号：US07566450B2

公开(公告)日：2009-07-28

申请号：US11924794

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20080241923A1

公开(公告)日：2008-10-02

申请号：US11924153

申请日：2007-10-25

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： C12N5/06

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US20090169541A1

公开(公告)日：2009-07-02

申请号：US11925080

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P35/00

CPC分类号： C07K14/7158 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2319/00

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

摘要翻译： 本发明涉及与哺乳动物（例如人）CC趋化因子受体2（CCR2）或受体的一部分结合并阻断配体与受体的结合的人源化抗体或其功能片段。 本发明还涉及抑制携带哺乳动物CCR2的细胞与其配体的相互作用的方法，以及在治疗，预防和诊断方法中使用抗体和片段。

公开(公告)号：US20090142339A1

公开(公告)日：2009-06-04

申请号：US11924783

申请日：2007-10-26

申请人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

发明人： Gregory J. LaRosa ,  Christopher J. Horvath ,  Walter Newman ,  S. Tarran Jones ,  Siobhan H. O'Brien ,  Theresa O'Keefe

IPC分类号： A61K39/395 ,  A61P37/02

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/76

摘要： The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.

公开(公告)号：US06663863B2

公开(公告)日：2003-12-16

申请号：US09809739

申请日：2001-03-15

申请人： Christopher J. Horvath ,  Patricia E. Rao

发明人： Christopher J. Horvath ,  Patricia E. Rao

IPC分类号： A61K39395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  A61M25/104 ,  C07K16/2845 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2319/00

摘要： The invention relates to a method of inhibiting stenosis or restenosis in a subject. In one embodiment, an agent which inhibits recruitment and/or adhesion of neutrophils and mononuclear cells to a site of vascular injury is administered to a subject in need thereof. In another embodiment, a first agent which inhibits recruitment and/or adhesion of neutrophils to a site of vascular injury, and a second agent which inhibits recruitment and/or adhesion of mononuclear cells to a site of vascular injury are administered to a subject in need thereof. In particular embodiments, the agents are antibodies or antigen-binding fragments thereof which bind to CD18 or CCR2.

摘要翻译： 本发明涉及一种抑制受试者狭窄或再狭窄的方法。 在一个实施方案中，向有需要的受试者施用抑制嗜中性粒细胞和单核细胞向血管损伤部位的募集和/或粘附的药剂。 在另一个实施方案中，将抑制嗜中性粒细胞募集和/或粘附到血管损伤部位的第一药剂和抑制单核细胞募集和/或粘附到血管损伤部位的第二药剂施用于需要的受试者 其中。 在具体实施方案中，所述试剂是结合CD18或CCR2的抗体或其抗原结合片段。